Abstract
Most endocrine hormones are produced in tissues and organs with permeable microvessels that may provide an excess of hormones to be transported by the blood circulation to the distal target organ. Here, we investigate whether leptin, an endocrine hormone, induces the formation of vascular fenestrations and permeability, and we characterize its angiogenic property in the presence of other angiogenic factors. We provide evidence that leptininduced new blood vessels are fenestrated. Under physiological conditions, capillary fenestrations are found in the leptin-producing adipose tissue in lean mice. In contrast, no vascular fenestrations were detected in the adipose tissue of leptin-deficient ob/ob mice. Thus, leptin plays a critical role in the maintenance and regulation of vascular fenestrations in the adipose tissue. Leptin induces a rapid vascular permeability response when administrated intradermally. Further, leptin synergistically stimulates angiogenesis with fibroblast growth factor (FGF)-2 and vascular endothelial growth factor (VEGF), the two most potent and commonly expressed angiogenic factors. These findings demonstrate that leptin has another new function - The increase of vascular permeability.
| Original language | English |
|---|---|
| Pages (from-to) | 6390-6395 |
| Number of pages | 6 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 98 |
| Issue number | 11 |
| DOIs | |
| State | Published - May 22 2001 |
| Externally published | Yes |
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Keywords
- Leptin
- Neovascularization
- Obesity
- Vascular fenestrations
ASJC Scopus subject areas
- Genetics
- General
Cite this
Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF. / Cao, Renhai; Brakenhielm, Ebba; Wahlestedt, Claes R; Thyberg, Johan; Cao, Yihai.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, No. 11, 22.05.2001, p. 6390-6395.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Leptin induces vascular permeability and synergistically stimulates angiogenesis with FGF-2 and VEGF
AU - Cao, Renhai
AU - Brakenhielm, Ebba
AU - Wahlestedt, Claes R
AU - Thyberg, Johan
AU - Cao, Yihai
PY - 2001/5/22
Y1 - 2001/5/22
N2 - Most endocrine hormones are produced in tissues and organs with permeable microvessels that may provide an excess of hormones to be transported by the blood circulation to the distal target organ. Here, we investigate whether leptin, an endocrine hormone, induces the formation of vascular fenestrations and permeability, and we characterize its angiogenic property in the presence of other angiogenic factors. We provide evidence that leptininduced new blood vessels are fenestrated. Under physiological conditions, capillary fenestrations are found in the leptin-producing adipose tissue in lean mice. In contrast, no vascular fenestrations were detected in the adipose tissue of leptin-deficient ob/ob mice. Thus, leptin plays a critical role in the maintenance and regulation of vascular fenestrations in the adipose tissue. Leptin induces a rapid vascular permeability response when administrated intradermally. Further, leptin synergistically stimulates angiogenesis with fibroblast growth factor (FGF)-2 and vascular endothelial growth factor (VEGF), the two most potent and commonly expressed angiogenic factors. These findings demonstrate that leptin has another new function - The increase of vascular permeability.
AB - Most endocrine hormones are produced in tissues and organs with permeable microvessels that may provide an excess of hormones to be transported by the blood circulation to the distal target organ. Here, we investigate whether leptin, an endocrine hormone, induces the formation of vascular fenestrations and permeability, and we characterize its angiogenic property in the presence of other angiogenic factors. We provide evidence that leptininduced new blood vessels are fenestrated. Under physiological conditions, capillary fenestrations are found in the leptin-producing adipose tissue in lean mice. In contrast, no vascular fenestrations were detected in the adipose tissue of leptin-deficient ob/ob mice. Thus, leptin plays a critical role in the maintenance and regulation of vascular fenestrations in the adipose tissue. Leptin induces a rapid vascular permeability response when administrated intradermally. Further, leptin synergistically stimulates angiogenesis with fibroblast growth factor (FGF)-2 and vascular endothelial growth factor (VEGF), the two most potent and commonly expressed angiogenic factors. These findings demonstrate that leptin has another new function - The increase of vascular permeability.
KW - Leptin
KW - Neovascularization
KW - Obesity
KW - Vascular fenestrations
UR - http://www.scopus.com/inward/record.url?scp=0035933126&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035933126&partnerID=8YFLogxK
U2 - 10.1073/pnas.101564798
DO - 10.1073/pnas.101564798
M3 - Article
C2 - 11344271
AN - SCOPUS:0035933126
VL - 98
SP - 6390
EP - 6395
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 11
ER -