Leptin and its association with somatic depressive symptoms in patients with the metabolic syndrome

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Abstract

Background: This study aimed to determine the association between circulating leptin levels and total depressive symptoms as well as depressive symptom dimensions (cognitive and somatic) after controlling for important confounding factors. Methods: The study sample was comprised of 135 participants with the metabolic syndrome. Depressive symptoms were measured using the Beck Depression Inventory - II. Leptin was measured using a leptin-specific enzyme immunoassay. Inflammation was assessed using C-reactive protein and interleukin-6 levels. Results: Leptin was significantly associated with somatic depressive symptoms (β = 0.33, P = 0.018), but not total depressive symptoms (β = 0.27, P = 0.067) or cognitive depressive symptoms (β = 0.21, P = 0.182), after controlling for age, gender, body mass index, and insulin resistance. Further adjustment for C-reactive protein and interleukin-6 levels did not alter the relationship (β = 0.32, P = 0.023) between circulating leptin levels and somatic depressive symptoms. Conclusions: Leptin is independently associated with somatic depressive symptoms in patients with the metabolic syndrome.

Original languageEnglish
Pages (from-to)31-39
Number of pages9
JournalAnnals of Behavioral Medicine
Volume46
Issue number1
DOIs
StatePublished - Aug 1 2013

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Leptin
Depression
C-Reactive Protein
Interleukin-6
Medically Unexplained Symptoms
Neurobehavioral Manifestations
Immunoenzyme Techniques
Insulin Resistance
Body Mass Index
Inflammation
Equipment and Supplies

Keywords

  • Blood pressure
  • Body weight
  • Cardiovascular disease
  • Depression
  • Inflammation
  • Insulin resistance
  • Leptin
  • Lipoproteins
  • Metabolic syndrome

ASJC Scopus subject areas

  • Psychology(all)
  • Psychiatry and Mental health
  • Medicine(all)

Cite this

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abstract = "Background: This study aimed to determine the association between circulating leptin levels and total depressive symptoms as well as depressive symptom dimensions (cognitive and somatic) after controlling for important confounding factors. Methods: The study sample was comprised of 135 participants with the metabolic syndrome. Depressive symptoms were measured using the Beck Depression Inventory - II. Leptin was measured using a leptin-specific enzyme immunoassay. Inflammation was assessed using C-reactive protein and interleukin-6 levels. Results: Leptin was significantly associated with somatic depressive symptoms (β = 0.33, P = 0.018), but not total depressive symptoms (β = 0.27, P = 0.067) or cognitive depressive symptoms (β = 0.21, P = 0.182), after controlling for age, gender, body mass index, and insulin resistance. Further adjustment for C-reactive protein and interleukin-6 levels did not alter the relationship (β = 0.32, P = 0.023) between circulating leptin levels and somatic depressive symptoms. Conclusions: Leptin is independently associated with somatic depressive symptoms in patients with the metabolic syndrome.",
keywords = "Blood pressure, Body weight, Cardiovascular disease, Depression, Inflammation, Insulin resistance, Leptin, Lipoproteins, Metabolic syndrome",
author = "Chirinos, {Diana A.} and Goldberg, {Ronald B} and Marc Gellman and Mendez, {Armando J} and Miriam Gutt and Judith McCalla and Maria Llabre and Neil Schneiderman",
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AU - Chirinos, Diana A.

AU - Goldberg, Ronald B

AU - Gellman, Marc

AU - Mendez, Armando J

AU - Gutt, Miriam

AU - McCalla, Judith

AU - Llabre, Maria

AU - Schneiderman, Neil

PY - 2013/8/1

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N2 - Background: This study aimed to determine the association between circulating leptin levels and total depressive symptoms as well as depressive symptom dimensions (cognitive and somatic) after controlling for important confounding factors. Methods: The study sample was comprised of 135 participants with the metabolic syndrome. Depressive symptoms were measured using the Beck Depression Inventory - II. Leptin was measured using a leptin-specific enzyme immunoassay. Inflammation was assessed using C-reactive protein and interleukin-6 levels. Results: Leptin was significantly associated with somatic depressive symptoms (β = 0.33, P = 0.018), but not total depressive symptoms (β = 0.27, P = 0.067) or cognitive depressive symptoms (β = 0.21, P = 0.182), after controlling for age, gender, body mass index, and insulin resistance. Further adjustment for C-reactive protein and interleukin-6 levels did not alter the relationship (β = 0.32, P = 0.023) between circulating leptin levels and somatic depressive symptoms. Conclusions: Leptin is independently associated with somatic depressive symptoms in patients with the metabolic syndrome.

AB - Background: This study aimed to determine the association between circulating leptin levels and total depressive symptoms as well as depressive symptom dimensions (cognitive and somatic) after controlling for important confounding factors. Methods: The study sample was comprised of 135 participants with the metabolic syndrome. Depressive symptoms were measured using the Beck Depression Inventory - II. Leptin was measured using a leptin-specific enzyme immunoassay. Inflammation was assessed using C-reactive protein and interleukin-6 levels. Results: Leptin was significantly associated with somatic depressive symptoms (β = 0.33, P = 0.018), but not total depressive symptoms (β = 0.27, P = 0.067) or cognitive depressive symptoms (β = 0.21, P = 0.182), after controlling for age, gender, body mass index, and insulin resistance. Further adjustment for C-reactive protein and interleukin-6 levels did not alter the relationship (β = 0.32, P = 0.023) between circulating leptin levels and somatic depressive symptoms. Conclusions: Leptin is independently associated with somatic depressive symptoms in patients with the metabolic syndrome.

KW - Blood pressure

KW - Body weight

KW - Cardiovascular disease

KW - Depression

KW - Inflammation

KW - Insulin resistance

KW - Leptin

KW - Lipoproteins

KW - Metabolic syndrome

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