Leptin and adiponectin mRNA expression from the adipose tissue surrounding the adrenal neoplasia

Claudio Letizia, Luigi Petramala, Cira Rosaria Tiziana Di Gioia, Caterina Chiappetta, Laura Zinnamosca, Cristiano Marinelli, Gino Iannucci, Antonio Ciardi, Giorgio De Toma, Gianluca Iacobellis

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Context: Interplay between adipose tissue and adrenal glands has been recently suggested, without well-founded actions of locally adipose tissue surrounding the adrenal glands. Objective: We hypothesized that the local expression of leptin and adiponectin can be associated with pathological changes of the adrenal glands. Patients and Main Outcome Measures: We evaluated RT-PCR of leptin and adiponectin mRNA expression from the adipose tissue surrounding adrenal glands in 30 patients, collecting adipose tissue surrounding the adrenal neoplasms, peri-renal and subcutaneous depots. Results: LeptinmRNAlevels from adrenal neoplasia and peri-renal fat were significantly higher in aldosterone-producing adenoma than in nonfunctioning adenomas (P < 0.001 and P < 0.02, respectively). In patients with Cushing's syndrome leptin mRNA levels were significantly higher in adrenal fat than in peri-renal (P < 0.05) and subcutaneous adipose tissue (P < 0.001). Adiponectin mRNA expression from adrenal neoplasia was significantly lower than that from peri-renal and subcutaneous fat depots (P < 0.05). Leptin and adiponectin plasma levels significantly correlated with their mRNA expression from the fat depot surrounding the adrenal neoplasia. Conclusions: Our findings suggest an active role of the fat depot surrounding the adrenal neoplasia, with local secretion of leptin and adiponectin.

Original languageEnglish
Pages (from-to)E101-E104
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Fingerprint

Adiponectin
Leptin
Adipose Tissue
Adrenal Glands
Fats
Tissue
Messenger RNA
Kidney
Subcutaneous Fat
Neoplasms
Adenoma
Adrenal Gland Neoplasms
Cushing Syndrome
Aldosterone
Outcome Assessment (Health Care)
Plasmas
Polymerase Chain Reaction

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Leptin and adiponectin mRNA expression from the adipose tissue surrounding the adrenal neoplasia. / Letizia, Claudio; Petramala, Luigi; Di Gioia, Cira Rosaria Tiziana; Chiappetta, Caterina; Zinnamosca, Laura; Marinelli, Cristiano; Iannucci, Gino; Ciardi, Antonio; De Toma, Giorgio; Iacobellis, Gianluca.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 100, No. 1, 01.01.2015, p. E101-E104.

Research output: Contribution to journalArticle

Letizia, C, Petramala, L, Di Gioia, CRT, Chiappetta, C, Zinnamosca, L, Marinelli, C, Iannucci, G, Ciardi, A, De Toma, G & Iacobellis, G 2015, 'Leptin and adiponectin mRNA expression from the adipose tissue surrounding the adrenal neoplasia', Journal of Clinical Endocrinology and Metabolism, vol. 100, no. 1, pp. E101-E104. https://doi.org/10.1210/jc.20142274
Letizia, Claudio ; Petramala, Luigi ; Di Gioia, Cira Rosaria Tiziana ; Chiappetta, Caterina ; Zinnamosca, Laura ; Marinelli, Cristiano ; Iannucci, Gino ; Ciardi, Antonio ; De Toma, Giorgio ; Iacobellis, Gianluca. / Leptin and adiponectin mRNA expression from the adipose tissue surrounding the adrenal neoplasia. In: Journal of Clinical Endocrinology and Metabolism. 2015 ; Vol. 100, No. 1. pp. E101-E104.
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