Leptin and adiponectin mRNA expression from the adipose tissue surrounding the adrenal neoplasia

Claudio Letizia, Luigi Petramala, Cira Rosaria Tiziana Di Gioia, Caterina Chiappetta, Laura Zinnamosca, Cristiano Marinelli, Gino Iannucci, Antonio Ciardi, Giorgio De Toma, Gianluca Iacobellis

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Context: Interplay between adipose tissue and adrenal glands has been recently suggested, without well-founded actions of locally adipose tissue surrounding the adrenal glands. Objective: We hypothesized that the local expression of leptin and adiponectin can be associated with pathological changes of the adrenal glands. Patients and Main Outcome Measures: We evaluated RT-PCR of leptin and adiponectin mRNA expression from the adipose tissue surrounding adrenal glands in 30 patients, collecting adipose tissue surrounding the adrenal neoplasms, peri-renal and subcutaneous depots. Results: LeptinmRNAlevels from adrenal neoplasia and peri-renal fat were significantly higher in aldosterone-producing adenoma than in nonfunctioning adenomas (P < 0.001 and P < 0.02, respectively). In patients with Cushing's syndrome leptin mRNA levels were significantly higher in adrenal fat than in peri-renal (P < 0.05) and subcutaneous adipose tissue (P < 0.001). Adiponectin mRNA expression from adrenal neoplasia was significantly lower than that from peri-renal and subcutaneous fat depots (P < 0.05). Leptin and adiponectin plasma levels significantly correlated with their mRNA expression from the fat depot surrounding the adrenal neoplasia. Conclusions: Our findings suggest an active role of the fat depot surrounding the adrenal neoplasia, with local secretion of leptin and adiponectin.

Original languageEnglish (US)
Pages (from-to)E101-E104
JournalJournal of Clinical Endocrinology and Metabolism
Volume100
Issue number1
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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    Letizia, C., Petramala, L., Di Gioia, C. R. T., Chiappetta, C., Zinnamosca, L., Marinelli, C., Iannucci, G., Ciardi, A., De Toma, G., & Iacobellis, G. (2015). Leptin and adiponectin mRNA expression from the adipose tissue surrounding the adrenal neoplasia. Journal of Clinical Endocrinology and Metabolism, 100(1), E101-E104. https://doi.org/10.1210/jc.2014-2274