Leg Ulcers Following Subcutaneous Injection of a Liquid Silicone Preparation

Virginia Rae, Rube J. Pardo, Patricia L. Blackwelder, Vincent Falanga

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


We present an unusual case of leg ulcers occurring 23 years after the patient had received large-volume subcutaneous injections of a liquid silicone preparation into her legs for cosmetic reasons. Light microscopy of a biopsy specimen from the edge of the ulcer showed optically clear vacuoles in the dermis, together with a mixed cellular infiltrate. Scanning electron microscopic studies revealed amorphous spherules within the vacuoles, and energy-dispersive spectroscopy established the presence of silicon in these spherules. Nearby tissue not containing spherules did not show a silicon peak. This case adds to the growing documentation of morbidity associated with injections of silicone of uncertain purity.

Original languageEnglish (US)
Pages (from-to)670-673
Number of pages4
JournalArchives of dermatology
Issue number5
StatePublished - May 1989

ASJC Scopus subject areas

  • Dermatology


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