Abstract
The clinical manifestations of the antiphospholipid antibody syndrome (APLA) include thrombosis, thrombocytopenia and recurrent fetal loss. Livedo reticularis and leg ulceration may occur as the result of vascular occlusion, and are difficult to treat. We report a patient with a painful leg ulceration and livedo reticularis secondary to APLA in whom intralesional triamcinolone injections induced rapid and complete healing of the ulceration. A year later, the ulcer has not recurred. Initial and prolonged treatment with stanozolol, an androgenic steroid with fibrinolytic properties that has been proposed as a treatment for this condition, seemed to help at first but failed to cause persistent healing. We suggest that intralesional injection of corticosteroids should be the initial treatment of choice in ulcers due to APLA.
| Original language | English |
|---|---|
| Pages (from-to) | 174-177 |
| Number of pages | 4 |
| Journal | Journal of the European Academy of Dermatology and Venereology |
| Volume | 3 |
| Issue number | 2 |
| State | Published - Mar 1 1994 |
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Keywords
- Antiphospholipid syndrome
- Corticosteroid
- Stanozolol
- Ulcer
ASJC Scopus subject areas
- Infectious Diseases
- Dermatology
Cite this
Leg ulceration due to the antiphospholipid syndrome : successful treatment with intralesional corticosteroids and failure of prolonged stanozolol therapy. / Falanga, Vincent; Brown, Harvey; Pardes, Jeffrey; Kirsner, Robert.
In: Journal of the European Academy of Dermatology and Venereology, Vol. 3, No. 2, 01.03.1994, p. 174-177.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Leg ulceration due to the antiphospholipid syndrome
T2 - successful treatment with intralesional corticosteroids and failure of prolonged stanozolol therapy
AU - Falanga, Vincent
AU - Brown, Harvey
AU - Pardes, Jeffrey
AU - Kirsner, Robert
PY - 1994/3/1
Y1 - 1994/3/1
N2 - The clinical manifestations of the antiphospholipid antibody syndrome (APLA) include thrombosis, thrombocytopenia and recurrent fetal loss. Livedo reticularis and leg ulceration may occur as the result of vascular occlusion, and are difficult to treat. We report a patient with a painful leg ulceration and livedo reticularis secondary to APLA in whom intralesional triamcinolone injections induced rapid and complete healing of the ulceration. A year later, the ulcer has not recurred. Initial and prolonged treatment with stanozolol, an androgenic steroid with fibrinolytic properties that has been proposed as a treatment for this condition, seemed to help at first but failed to cause persistent healing. We suggest that intralesional injection of corticosteroids should be the initial treatment of choice in ulcers due to APLA.
AB - The clinical manifestations of the antiphospholipid antibody syndrome (APLA) include thrombosis, thrombocytopenia and recurrent fetal loss. Livedo reticularis and leg ulceration may occur as the result of vascular occlusion, and are difficult to treat. We report a patient with a painful leg ulceration and livedo reticularis secondary to APLA in whom intralesional triamcinolone injections induced rapid and complete healing of the ulceration. A year later, the ulcer has not recurred. Initial and prolonged treatment with stanozolol, an androgenic steroid with fibrinolytic properties that has been proposed as a treatment for this condition, seemed to help at first but failed to cause persistent healing. We suggest that intralesional injection of corticosteroids should be the initial treatment of choice in ulcers due to APLA.
KW - Antiphospholipid syndrome
KW - Corticosteroid
KW - Stanozolol
KW - Ulcer
UR - http://www.scopus.com/inward/record.url?scp=0028213090&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028213090&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0028213090
VL - 3
SP - 174
EP - 177
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
SN - 0926-9959
IS - 2
ER -