Left ventricular performance in mitral regurgitation assessed with systolic time intervals and echocardiography

Kenneth L. Wanderman, Mark J. Goldberg, Richard S. Stack, Arnold M. Weissler

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14 Scopus citations


Among 22 patients with isolated mitral regurgitation of various origins, systolic time intervals (preejection period [PEP] index, left ventricular ejection time [LVET] index and PEP/LVET) and echocardiographic measures of left ventricular performance (end-diastolic diameter [Dd], end-systolic diameter [Ds], and the percent change in minor axis diameter [%ΔD]) were calculated. The patients were classified into two groups, those with a normal or supernormal %ΔD (group I, 15 patients) and those with a decreased %ΔD (group II, 7 patients). On group analysis, prolongation of the preejection period, shortening of the left ventricular ejection time and an increase in PEP/LVET was generally characteristic of patients with mitral regurgitation. These changes were accentuated when mitral regurgitation was complicated by echocardiographic evidence of diminished left ventricular contractile performance (%ΔD less than 30 percent). An increase in PEP/LVET to greater than 0.50 was consistently associated with abnormal left ventricular performance, whereas a normal PEP/LVET ratio reflected normal or supernormal left ventricular performance. An inverse linear relation was found between PEP/LVET and %ΔD. When compared with previous data on the relation of these variables among patients without valve insufficiency, PEP/LVET proved to be increased for any level of %ΔD in mitral regurgitation. The state of digitalization did not appear to influence the relation between PEP/LVET and %ΔD. The use of echocardiographic measurements augments the determination of systolic time intervals in the analysis of left ventricular performance in patients with mitral regurgitation.

Original languageEnglish (US)
Pages (from-to)831-835
Number of pages5
JournalThe American Journal of Cardiology
Issue number7
StatePublished - Dec 1976

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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