Abstract
Background Although abnormal left ventricular geometric patterns have prognostic value for morbidity and mortality, their possible association with silent cerebrovascular disease has not been extensively evaluated. Methods We examined 665 participants in the CABL study who underwent transthoracic echocardiography and brain magnetic resonance imaging. Participants were divided into 4 geometric patterns: normal geometry (n = 397), concentric remodeling (n = 89), eccentric hypertrophy (n = 126), and concentric hypertrophy (n = 53). Subclinical cerebrovascular disease was defined as silent brain infarcts (SBIs) and white matter hyperintensity volume (WMHV; expressed as log-transformed percentage of the total cranial volume). Results Silent brain infarcts were observed in 94 participants (14%). Mean log-WMHV was −0.97 ± 0.93. Concentric hypertrophy carried the greatest risk for both SBI (adjusted odds ratio [OR] 3.39, P < .001) and upper quartile of log-WMHV (adjusted OR 3.35, P < .001), followed by eccentric hypertrophy (adjusted ORs 2.52 [P = .001 for SBI] and 1.96 [P = .004] for log-WMHV). Concentric remodeling was not associated with subclinical brain disease. In subgroup analyses, concentric and eccentric hypertrophies were significantly associated with SBI and WMHV in both genders and nonobese participants, but differed for SBI by age (all ages for eccentric hypertrophy, only patients ≥70 years for concentric hypertrophy) and by race-ethnicity (Hispanics for eccentric hypertrophy, blacks for concentric hypertrophy; no association in whites). Conclusions Left ventricular hypertrophy, with both eccentric and concentric patterns, was significantly associated with subclinical cerebrovascular disease in a multiethnic stroke-free general population. Left ventricular geometric patterns may carry different risks for silent cerebrovascular disease in different sex, age, race-ethnic, and body size subgroups.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 85-92 |
| Number of pages | 8 |
| Journal | American Heart Journal |
| Volume | 185 |
| DOIs | |
| State | Published - Mar 1 2017 |
Fingerprint
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Left ventricular mass-geometry and silent cerebrovascular disease : The Cardiovascular Abnormalities and Brain Lesions (CABL) study. / Nakanishi, Koki; Jin, Zhezhen; Homma, Shunichi; Elkind, Mitchell S V; Rundek, Tatjana; Tugcu, Aylin; Yoshita, Mitsuhiro; DeCarli, Charles; Wright, Clinton B; Sacco, Ralph L; Di Tullio, Marco R.
In: American Heart Journal, Vol. 185, 01.03.2017, p. 85-92.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Left ventricular mass-geometry and silent cerebrovascular disease
T2 - The Cardiovascular Abnormalities and Brain Lesions (CABL) study
AU - Nakanishi, Koki
AU - Jin, Zhezhen
AU - Homma, Shunichi
AU - Elkind, Mitchell S V
AU - Rundek, Tatjana
AU - Tugcu, Aylin
AU - Yoshita, Mitsuhiro
AU - DeCarli, Charles
AU - Wright, Clinton B
AU - Sacco, Ralph L
AU - Di Tullio, Marco R.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Background Although abnormal left ventricular geometric patterns have prognostic value for morbidity and mortality, their possible association with silent cerebrovascular disease has not been extensively evaluated. Methods We examined 665 participants in the CABL study who underwent transthoracic echocardiography and brain magnetic resonance imaging. Participants were divided into 4 geometric patterns: normal geometry (n = 397), concentric remodeling (n = 89), eccentric hypertrophy (n = 126), and concentric hypertrophy (n = 53). Subclinical cerebrovascular disease was defined as silent brain infarcts (SBIs) and white matter hyperintensity volume (WMHV; expressed as log-transformed percentage of the total cranial volume). Results Silent brain infarcts were observed in 94 participants (14%). Mean log-WMHV was −0.97 ± 0.93. Concentric hypertrophy carried the greatest risk for both SBI (adjusted odds ratio [OR] 3.39, P < .001) and upper quartile of log-WMHV (adjusted OR 3.35, P < .001), followed by eccentric hypertrophy (adjusted ORs 2.52 [P = .001 for SBI] and 1.96 [P = .004] for log-WMHV). Concentric remodeling was not associated with subclinical brain disease. In subgroup analyses, concentric and eccentric hypertrophies were significantly associated with SBI and WMHV in both genders and nonobese participants, but differed for SBI by age (all ages for eccentric hypertrophy, only patients ≥70 years for concentric hypertrophy) and by race-ethnicity (Hispanics for eccentric hypertrophy, blacks for concentric hypertrophy; no association in whites). Conclusions Left ventricular hypertrophy, with both eccentric and concentric patterns, was significantly associated with subclinical cerebrovascular disease in a multiethnic stroke-free general population. Left ventricular geometric patterns may carry different risks for silent cerebrovascular disease in different sex, age, race-ethnic, and body size subgroups.
AB - Background Although abnormal left ventricular geometric patterns have prognostic value for morbidity and mortality, their possible association with silent cerebrovascular disease has not been extensively evaluated. Methods We examined 665 participants in the CABL study who underwent transthoracic echocardiography and brain magnetic resonance imaging. Participants were divided into 4 geometric patterns: normal geometry (n = 397), concentric remodeling (n = 89), eccentric hypertrophy (n = 126), and concentric hypertrophy (n = 53). Subclinical cerebrovascular disease was defined as silent brain infarcts (SBIs) and white matter hyperintensity volume (WMHV; expressed as log-transformed percentage of the total cranial volume). Results Silent brain infarcts were observed in 94 participants (14%). Mean log-WMHV was −0.97 ± 0.93. Concentric hypertrophy carried the greatest risk for both SBI (adjusted odds ratio [OR] 3.39, P < .001) and upper quartile of log-WMHV (adjusted OR 3.35, P < .001), followed by eccentric hypertrophy (adjusted ORs 2.52 [P = .001 for SBI] and 1.96 [P = .004] for log-WMHV). Concentric remodeling was not associated with subclinical brain disease. In subgroup analyses, concentric and eccentric hypertrophies were significantly associated with SBI and WMHV in both genders and nonobese participants, but differed for SBI by age (all ages for eccentric hypertrophy, only patients ≥70 years for concentric hypertrophy) and by race-ethnicity (Hispanics for eccentric hypertrophy, blacks for concentric hypertrophy; no association in whites). Conclusions Left ventricular hypertrophy, with both eccentric and concentric patterns, was significantly associated with subclinical cerebrovascular disease in a multiethnic stroke-free general population. Left ventricular geometric patterns may carry different risks for silent cerebrovascular disease in different sex, age, race-ethnic, and body size subgroups.
UR - http://www.scopus.com/inward/record.url?scp=85008470420&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85008470420&partnerID=8YFLogxK
U2 - 10.1016/j.ahj.2016.11.010
DO - 10.1016/j.ahj.2016.11.010
M3 - Article
C2 - 28267479
AN - SCOPUS:85008470420
VL - 185
SP - 85
EP - 92
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
ER -