Left atrial 4-dimensional flow magnetic resonance imaging stasis and velocity mapping in patients with atrial fibrillation

Michael Markl, Daniel C. Lee, Jason Ng, Maria Carr, James Carr, Jeffrey Goldberger

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objectives: Left atrial (LA) 4-dimensional flow magnetic resonance imaging (MRI) was used to derive anatomic maps of LA stasis, peak velocity, and timeto- peak (TTP) velocity in patients with atrial fibrillation (AF) and to identify relationships between LA flow with LAvolume and patient characteristics. Materials and Methods: Four-dimensional flow MRI for the in vivo assessment of time-resolved 3-dimensional LA blood flow velocities was performed in 111 subjects: 42 patients with a history of AF and in sinus rhythm (AFsinus), 39 patients with persistent AF (AF-afib), 10 young healthy volunteers (HVs), and 20 age-appropriate controls (CTRL). Data analysis included the 3-dimensional segmentation of the LA and the calculation of LA stasis, peak velocity, and TTPmaps. Regional LAflowdynamicswere quantified by calculating mean stasis, peak velocity, and TTP in the LA center region and the region adjacent to the LAwall. Results: A sensitivity analysis identified thresholds for global LA stasis (<0.1 m/s) and peak velocity (top 5% LAvelocities), which detected significant differences between AF patients and controls for global LA stasis (HV, 25% ± 5%; CTRL, 29% ± 10%; AF-sinus, 41% ± 13%; AF-afib, 52% ± 17%) and peak velocity (HV, 0.43 ± 0.02 m/s; CTRL, 0.37 ± 0.04 m/s; AF-sinus, 0.33 ± 0.05 m/s; AF-afib, 0.30 ± 0.05 m/s). Regional analysis revealed significantly increased stasis at both LA center and wall for AF patients compared with ageappropriate controls (29%-84% difference, P < 0.006) and for AF-afib versus AF-sinus patients (22%-30% difference, P < 0.004). In addition, stasis close to the LAwall was significantly elevated (P < 0.001) compared with the LA center for all subject groups. Multiple regressions revealed significant (R2 Adj = 0.45- 0.50, P < 0.001) relationships between impaired global LA flow (reduced velocity and increased stasis) with age (/β/ = 0.27-0.50, P < 0.002) and LA volume (/β/ = 0.26-0.50, P < 0.003). Conclusions: Atrial 4-dimensional flow MRI detected changes in global and regional LA flow dynamics associated with AF, age, and LAvolume. Longitudinal studies are needed to test the diagnostic value of LA flow metrics as potential risk factors for thromboembolic events.

Original languageEnglish (US)
Pages (from-to)147-154
Number of pages8
JournalInvestigative Radiology
Volume51
Issue number3
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

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Atrial Fibrillation
Magnetic Resonance Imaging
Healthy Volunteers
Blood Flow Velocity
Routine Diagnostic Tests
Longitudinal Studies

Keywords

  • 4D flow MRI
  • Atrial fibrillation
  • Left atrium
  • Peak velocity
  • Stasis
  • Stroke

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Left atrial 4-dimensional flow magnetic resonance imaging stasis and velocity mapping in patients with atrial fibrillation. / Markl, Michael; Lee, Daniel C.; Ng, Jason; Carr, Maria; Carr, James; Goldberger, Jeffrey.

In: Investigative Radiology, Vol. 51, No. 3, 01.01.2016, p. 147-154.

Research output: Contribution to journalArticle

Markl, Michael ; Lee, Daniel C. ; Ng, Jason ; Carr, Maria ; Carr, James ; Goldberger, Jeffrey. / Left atrial 4-dimensional flow magnetic resonance imaging stasis and velocity mapping in patients with atrial fibrillation. In: Investigative Radiology. 2016 ; Vol. 51, No. 3. pp. 147-154.
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abstract = "Objectives: Left atrial (LA) 4-dimensional flow magnetic resonance imaging (MRI) was used to derive anatomic maps of LA stasis, peak velocity, and timeto- peak (TTP) velocity in patients with atrial fibrillation (AF) and to identify relationships between LA flow with LAvolume and patient characteristics. Materials and Methods: Four-dimensional flow MRI for the in vivo assessment of time-resolved 3-dimensional LA blood flow velocities was performed in 111 subjects: 42 patients with a history of AF and in sinus rhythm (AFsinus), 39 patients with persistent AF (AF-afib), 10 young healthy volunteers (HVs), and 20 age-appropriate controls (CTRL). Data analysis included the 3-dimensional segmentation of the LA and the calculation of LA stasis, peak velocity, and TTPmaps. Regional LAflowdynamicswere quantified by calculating mean stasis, peak velocity, and TTP in the LA center region and the region adjacent to the LAwall. Results: A sensitivity analysis identified thresholds for global LA stasis (<0.1 m/s) and peak velocity (top 5{\%} LAvelocities), which detected significant differences between AF patients and controls for global LA stasis (HV, 25{\%} ± 5{\%}; CTRL, 29{\%} ± 10{\%}; AF-sinus, 41{\%} ± 13{\%}; AF-afib, 52{\%} ± 17{\%}) and peak velocity (HV, 0.43 ± 0.02 m/s; CTRL, 0.37 ± 0.04 m/s; AF-sinus, 0.33 ± 0.05 m/s; AF-afib, 0.30 ± 0.05 m/s). Regional analysis revealed significantly increased stasis at both LA center and wall for AF patients compared with ageappropriate controls (29{\%}-84{\%} difference, P < 0.006) and for AF-afib versus AF-sinus patients (22{\%}-30{\%} difference, P < 0.004). In addition, stasis close to the LAwall was significantly elevated (P < 0.001) compared with the LA center for all subject groups. Multiple regressions revealed significant (R2 Adj = 0.45- 0.50, P < 0.001) relationships between impaired global LA flow (reduced velocity and increased stasis) with age (/β/ = 0.27-0.50, P < 0.002) and LA volume (/β/ = 0.26-0.50, P < 0.003). Conclusions: Atrial 4-dimensional flow MRI detected changes in global and regional LA flow dynamics associated with AF, age, and LAvolume. Longitudinal studies are needed to test the diagnostic value of LA flow metrics as potential risk factors for thromboembolic events.",
keywords = "4D flow MRI, Atrial fibrillation, Left atrium, Peak velocity, Stasis, Stroke",
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T1 - Left atrial 4-dimensional flow magnetic resonance imaging stasis and velocity mapping in patients with atrial fibrillation

AU - Markl, Michael

AU - Lee, Daniel C.

AU - Ng, Jason

AU - Carr, Maria

AU - Carr, James

AU - Goldberger, Jeffrey

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Objectives: Left atrial (LA) 4-dimensional flow magnetic resonance imaging (MRI) was used to derive anatomic maps of LA stasis, peak velocity, and timeto- peak (TTP) velocity in patients with atrial fibrillation (AF) and to identify relationships between LA flow with LAvolume and patient characteristics. Materials and Methods: Four-dimensional flow MRI for the in vivo assessment of time-resolved 3-dimensional LA blood flow velocities was performed in 111 subjects: 42 patients with a history of AF and in sinus rhythm (AFsinus), 39 patients with persistent AF (AF-afib), 10 young healthy volunteers (HVs), and 20 age-appropriate controls (CTRL). Data analysis included the 3-dimensional segmentation of the LA and the calculation of LA stasis, peak velocity, and TTPmaps. Regional LAflowdynamicswere quantified by calculating mean stasis, peak velocity, and TTP in the LA center region and the region adjacent to the LAwall. Results: A sensitivity analysis identified thresholds for global LA stasis (<0.1 m/s) and peak velocity (top 5% LAvelocities), which detected significant differences between AF patients and controls for global LA stasis (HV, 25% ± 5%; CTRL, 29% ± 10%; AF-sinus, 41% ± 13%; AF-afib, 52% ± 17%) and peak velocity (HV, 0.43 ± 0.02 m/s; CTRL, 0.37 ± 0.04 m/s; AF-sinus, 0.33 ± 0.05 m/s; AF-afib, 0.30 ± 0.05 m/s). Regional analysis revealed significantly increased stasis at both LA center and wall for AF patients compared with ageappropriate controls (29%-84% difference, P < 0.006) and for AF-afib versus AF-sinus patients (22%-30% difference, P < 0.004). In addition, stasis close to the LAwall was significantly elevated (P < 0.001) compared with the LA center for all subject groups. Multiple regressions revealed significant (R2 Adj = 0.45- 0.50, P < 0.001) relationships between impaired global LA flow (reduced velocity and increased stasis) with age (/β/ = 0.27-0.50, P < 0.002) and LA volume (/β/ = 0.26-0.50, P < 0.003). Conclusions: Atrial 4-dimensional flow MRI detected changes in global and regional LA flow dynamics associated with AF, age, and LAvolume. Longitudinal studies are needed to test the diagnostic value of LA flow metrics as potential risk factors for thromboembolic events.

AB - Objectives: Left atrial (LA) 4-dimensional flow magnetic resonance imaging (MRI) was used to derive anatomic maps of LA stasis, peak velocity, and timeto- peak (TTP) velocity in patients with atrial fibrillation (AF) and to identify relationships between LA flow with LAvolume and patient characteristics. Materials and Methods: Four-dimensional flow MRI for the in vivo assessment of time-resolved 3-dimensional LA blood flow velocities was performed in 111 subjects: 42 patients with a history of AF and in sinus rhythm (AFsinus), 39 patients with persistent AF (AF-afib), 10 young healthy volunteers (HVs), and 20 age-appropriate controls (CTRL). Data analysis included the 3-dimensional segmentation of the LA and the calculation of LA stasis, peak velocity, and TTPmaps. Regional LAflowdynamicswere quantified by calculating mean stasis, peak velocity, and TTP in the LA center region and the region adjacent to the LAwall. Results: A sensitivity analysis identified thresholds for global LA stasis (<0.1 m/s) and peak velocity (top 5% LAvelocities), which detected significant differences between AF patients and controls for global LA stasis (HV, 25% ± 5%; CTRL, 29% ± 10%; AF-sinus, 41% ± 13%; AF-afib, 52% ± 17%) and peak velocity (HV, 0.43 ± 0.02 m/s; CTRL, 0.37 ± 0.04 m/s; AF-sinus, 0.33 ± 0.05 m/s; AF-afib, 0.30 ± 0.05 m/s). Regional analysis revealed significantly increased stasis at both LA center and wall for AF patients compared with ageappropriate controls (29%-84% difference, P < 0.006) and for AF-afib versus AF-sinus patients (22%-30% difference, P < 0.004). In addition, stasis close to the LAwall was significantly elevated (P < 0.001) compared with the LA center for all subject groups. Multiple regressions revealed significant (R2 Adj = 0.45- 0.50, P < 0.001) relationships between impaired global LA flow (reduced velocity and increased stasis) with age (/β/ = 0.27-0.50, P < 0.002) and LA volume (/β/ = 0.26-0.50, P < 0.003). Conclusions: Atrial 4-dimensional flow MRI detected changes in global and regional LA flow dynamics associated with AF, age, and LAvolume. Longitudinal studies are needed to test the diagnostic value of LA flow metrics as potential risk factors for thromboembolic events.

KW - 4D flow MRI

KW - Atrial fibrillation

KW - Left atrium

KW - Peak velocity

KW - Stasis

KW - Stroke

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