Abstract
Obesity is accompanied by chronic, low-grade inflammation of adipose tissue, which promotes insulin resistance and type-2 diabetes. These findings raise the question of how fat inflammation can escape the powerful armamentarium of cells and molecules normally responsible for guarding against a runaway immune response. CD4+ Foxp3+ T regulatory (T(reg)) cells with a unique phenotype were highly enriched in the abdominal fat of normal mice, but their numbers were strikingly and specifically reduced at this site in insulin-resistant models of obesity. Loss-of-function and gain-of-function experiments revealed that these T(reg) cells influenced the inflammatory state of adipose tissue and, thus, insulin resistance. Cytokines differentially synthesized by fat-resident regulatory and conventional T cells directly affected the synthesis of inflammatory mediators and glucose uptake by cultured adipocytes. These observations suggest that harnessing the anti-inflammatory properties of T(reg) cells to inhibit elements of the metabolic syndrome may have therapeutic potential.
| Original language | English |
|---|---|
| Pages (from-to) | 930-939 |
| Number of pages | 10 |
| Journal | Nature Medicine |
| Volume | 15 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 1 2009 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Medicine(all)
Cite this
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. / Feuerer, Markus; Herrero, Laura; Cipolletta, Daniela; Naaz, Afia; Wong, Jamie; Nayer, Ali; Lee, Jongsoon; Goldfine, Allison B.; Benoist, Christophe; Shoelson, Steven; Mathis, Diane.
In: Nature Medicine, Vol. 15, No. 8, 01.08.2009, p. 930-939.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
AU - Feuerer, Markus
AU - Herrero, Laura
AU - Cipolletta, Daniela
AU - Naaz, Afia
AU - Wong, Jamie
AU - Nayer, Ali
AU - Lee, Jongsoon
AU - Goldfine, Allison B.
AU - Benoist, Christophe
AU - Shoelson, Steven
AU - Mathis, Diane
PY - 2009/8/1
Y1 - 2009/8/1
N2 - Obesity is accompanied by chronic, low-grade inflammation of adipose tissue, which promotes insulin resistance and type-2 diabetes. These findings raise the question of how fat inflammation can escape the powerful armamentarium of cells and molecules normally responsible for guarding against a runaway immune response. CD4+ Foxp3+ T regulatory (T(reg)) cells with a unique phenotype were highly enriched in the abdominal fat of normal mice, but their numbers were strikingly and specifically reduced at this site in insulin-resistant models of obesity. Loss-of-function and gain-of-function experiments revealed that these T(reg) cells influenced the inflammatory state of adipose tissue and, thus, insulin resistance. Cytokines differentially synthesized by fat-resident regulatory and conventional T cells directly affected the synthesis of inflammatory mediators and glucose uptake by cultured adipocytes. These observations suggest that harnessing the anti-inflammatory properties of T(reg) cells to inhibit elements of the metabolic syndrome may have therapeutic potential.
AB - Obesity is accompanied by chronic, low-grade inflammation of adipose tissue, which promotes insulin resistance and type-2 diabetes. These findings raise the question of how fat inflammation can escape the powerful armamentarium of cells and molecules normally responsible for guarding against a runaway immune response. CD4+ Foxp3+ T regulatory (T(reg)) cells with a unique phenotype were highly enriched in the abdominal fat of normal mice, but their numbers were strikingly and specifically reduced at this site in insulin-resistant models of obesity. Loss-of-function and gain-of-function experiments revealed that these T(reg) cells influenced the inflammatory state of adipose tissue and, thus, insulin resistance. Cytokines differentially synthesized by fat-resident regulatory and conventional T cells directly affected the synthesis of inflammatory mediators and glucose uptake by cultured adipocytes. These observations suggest that harnessing the anti-inflammatory properties of T(reg) cells to inhibit elements of the metabolic syndrome may have therapeutic potential.
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U2 - 10.1038/nm.2002
DO - 10.1038/nm.2002
M3 - Article
C2 - 19633656
AN - SCOPUS:68349148211
VL - 15
SP - 930
EP - 939
JO - Nature Medicine
JF - Nature Medicine
SN - 1078-8956
IS - 8
ER -