Layer-by-layer biosensor assembly incorporating functionalized quantum dots

Celeste A. Constantine, Kerim M. Gattás-Asfura, Sarita V. Mello, Gema Crespo, Vipin Rastogi, Tu Chen Cheng, Joseph J. DeFrank, Roger M. Leblanc

Research output: Contribution to journalArticle

121 Scopus citations

Abstract

Layer-by-layer (LbL) assembly has been utilized to fabricate an ultrathin film of polyelectrolytes. The architecture was composed of chitosan and organophosphorus hydrolase polycations along with thioglycolic acid-capped CdSe quantum dots (QDs) as the polyanion. The topography of the films was studied using epifluorescence microscopy imaging. The photoluminescence property of the functionalized QDs improved when sandwiched between the polycation layers. The enhanced optical property of QDs allowed easy monitoring of LbL growth and detection of paraoxon with high sensitivity. The presence of organophosphorus compounds was confirmed through UV-vis and emission spectroscopies.

Original languageEnglish (US)
Pages (from-to)9863-9867
Number of pages5
JournalLangmuir
Volume19
Issue number23
DOIs
StatePublished - Nov 11 2003

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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