Latest advances in adult gastrointestinal stromal tumors

Vaia Florou, Breelyn A. Wilky, Jonathan C. Trent

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

Gastrointestinal stromal tumors (GISTs) are the most common GI tract mesenchymal tumors. GIST patients are optimally managed by a precision medicine approach. Herein, we discuss the latest advances in precision medicine and ongoing clinical trials relevant to GIST. Circulating tumor DNA for detection of mutational changes could replace tissue biopsies and radiographic imaging once validated. Most GISTs are KIT/PDGFRα mutated, and despite the good clinical response to imatinib, treatment is generally not curative, more often due to secondary mutations. New mechanisms to bypass this resistance by inhibiting KIT downstream pathways and by targeting multiple KIT or PDGFRα mutations are being investigated. Immunotherapy for GIST patients is in its infancy. These approaches may lead to more effective, less toxic therapies.

Original languageEnglish (US)
Pages (from-to)2183-2193
Number of pages11
JournalFuture Oncology
Volume13
Issue number24
DOIs
StatePublished - Oct 2017

Keywords

  • GIST
  • KIT
  • PDGFRα
  • circulating tumor DNA
  • quadruple WT GIST

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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