Latent autoimmune diabetes in adults: The search for interventions continues

Research output: Contribution to journalArticle

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Abstract

This Practice Point commentary discusses the findings of a study by Maruyama et al., in which treatment with insulin was compared to sulfonylurea in 60 patients with slowly progressive insulin-dependent diabetes mellitus (SPIDDM), a presumed form of latent autoimmune diabetes in adults (LADA). Patients who received insulin had a lower rate of progression to insulin dependency than patients who received sulfonylurea (10% versus 43%, P = 0.003). Here, I review the history of LADA and the current approach to diagnosis and treatment. Diagnosis of LADA is generally by the detection of glutamic acid decarboxylase antibodies in adults who present with the clinical features of type 2 diabetes mellitus, providing presumptive evidence of autoimmunity. Treatment of LADA is usually with insulin, an approach supported by the findings of the study. Nonetheless, some evidence suggests that sulfonylurea actually accelerates loss of β-cell function. Whether this effect had a role in the results obtained by the Maruyama et al. is not yet clear.

Original languageEnglish
Pages (from-to)600-601
Number of pages2
JournalNature Clinical Practice Endocrinology and Metabolism
Volume4
Issue number11
DOIs
StatePublished - Nov 1 2008

Fingerprint

Insulin
Glutamate Decarboxylase
Autoimmunity
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Therapeutics
History
Latent Autoimmune Diabetes in Adults
Antibodies

Keywords

  • Insulin
  • Latent autoimmune diabetes in adults
  • Slowly progressive insulin-dependent diabetes mellitus
  • Sulfonylurea

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Latent autoimmune diabetes in adults : The search for interventions continues. / Skyler, Jay S.

In: Nature Clinical Practice Endocrinology and Metabolism, Vol. 4, No. 11, 01.11.2008, p. 600-601.

Research output: Contribution to journalArticle

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