Late-phase bronchial vascular responses in allergic sheep

W. M. Long, L. D. Yerger, W. M. Abraham, C. Lobel

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Sheep were classified on the basis of their airway response to Ascaris suum antigen aerosols as allergic or nonsensitive. Allergic sheep were classed as acute or dual responders. Acute responders had only an immediate increase in mean airflow resistance after antigen, whereas dual responders had an immediate and late-phase (6-8 h after antigen challenge) increase in mean airflow resistance; nonsensitive sheep had minimal airway responses to antigen (< 30% increase from base line). The sheep were anesthetized 2 wk later and, after a left thoracotomy, were challenged with antigen to determine bronchial vascular responses; bronchial artery blood flow was measured with an electromagnetic flow probe. Airway responses to antigen aerosol challenge were similar in the anesthetized and conscious animals. The mean fall in bronchial vascular resistance (BVR) immediately after antigen challenge was similar in acute and dual responders (41 ± 7 and 47 ± 9% of base line, respectively). In dual responders, late-phase airway responses were preceded by a significant increase from base line in Q̇br and a fall in bronchovascular resistance (BVR). The mean fall in BVR 6-8 h after antigen challenge in documented dual responders was significantly different from bronchial vascular responses in acute responders (59 ± 3 vs. 89 ± 10%, respectively). Sheep without airway responses to A. suum had no significant changes in bronchial hemodynamics or airways mechanics. Late-phase-associated changes in BVR are a specific response to antigen challenge and may be a sensitive index of mediators being released. We hypothesize that late-phase-associated changes in BVR may contribute to the increase in mean airflow resistance during late-phase responses by promoting edema formation.

Original languageEnglish
Pages (from-to)584-590
Number of pages7
JournalJournal of Applied Physiology
Volume69
Issue number2
StatePublished - Jan 1 1990
Externally publishedYes

Fingerprint

Blood Vessels
Sheep
Antigens
Vascular Resistance
Ascaris suum
Aerosols
Bronchial Arteries
Electromagnetic Phenomena
Thoracotomy
Mechanics
Edema
Hemodynamics

Keywords

  • Ascaris suum
  • bronchial artery blood flow
  • immediate hypersensitivity
  • late-phase allergic responses

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Long, W. M., Yerger, L. D., Abraham, W. M., & Lobel, C. (1990). Late-phase bronchial vascular responses in allergic sheep. Journal of Applied Physiology, 69(2), 584-590.

Late-phase bronchial vascular responses in allergic sheep. / Long, W. M.; Yerger, L. D.; Abraham, W. M.; Lobel, C.

In: Journal of Applied Physiology, Vol. 69, No. 2, 01.01.1990, p. 584-590.

Research output: Contribution to journalArticle

Long, WM, Yerger, LD, Abraham, WM & Lobel, C 1990, 'Late-phase bronchial vascular responses in allergic sheep', Journal of Applied Physiology, vol. 69, no. 2, pp. 584-590.
Long WM, Yerger LD, Abraham WM, Lobel C. Late-phase bronchial vascular responses in allergic sheep. Journal of Applied Physiology. 1990 Jan 1;69(2):584-590.
Long, W. M. ; Yerger, L. D. ; Abraham, W. M. ; Lobel, C. / Late-phase bronchial vascular responses in allergic sheep. In: Journal of Applied Physiology. 1990 ; Vol. 69, No. 2. pp. 584-590.
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