Abstract
Late graft loss (LGL) and late mortality (LM) following liver transplantation (LT) in children were analyzed from the studies of pediatric liver transplantation (SPLIT) database. Univariate and multivariate associations between pre- and postoperative factors and LGL and LM in 872 patients alive with their primary allografts 1 year after LT were reviewed. Thirty-four patients subsequently died (LM) and 35 patients underwent re-LT (LGL). Patients who survive the first posttransplant year had 5-year patient and graft survival rates of 94.2% and 89.2%, respectively. Graft loss after the first year was caused by rejection in 49% of the cases with sequelae of technical complications accounting for an additional 20% of LGL. LT for tumor, steroid resistant rejection, reoperation in the first 30 days and >5 admissions during the first posttransplant year were independently associated with LGL in multivariate analysis. Malignancy, infection, multiple system organ failure and posttransplant lymphoproliferative disease accounted for 61.8% of all late deaths after LT. LT performed for FHF and tumor were associated with LM. Patients who are at or below the mean for weight at the time of transplant were also at an increased risk of dying. Frequent readmission was also found to be associated with LM.
| Original language | English |
|---|---|
| Pages (from-to) | 2165-2171 |
| Number of pages | 7 |
| Journal | American Journal of Transplantation |
| Volume | 7 |
| Issue number | 9 |
| DOIs | |
| State | Published - Sep 1 2007 |
| Externally published | Yes |
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Keywords
- Immunosuppression
- Infection
- Long-term outcomes
- Malignancy
- Patient and graft survival
- Pediatric liver transplantation
ASJC Scopus subject areas
- Immunology
Cite this
Late graft loss or death in pediatric liver transplantation : an analysis of the SPLIT database. / Soltys, K. A.; Mazariegos, G. V.; Squires, R. H.; Sindhi, R. K.; Anand, R.; Dunn, Stephen; Manendez, Jerome; Flynn, Louise; Jonas, Maureen; Krawczuk, Laura; Christoff, Marielle; Kane, Robert; Solomon, Harvey; Phillips, Erin; Ferrer, Laurie; Heffron, Thomas; DePaolo, Jill; Pillen, Todd; Davis, Laurel; Bucuvalas, John; Ryckman, Fred; Hawkins, Andre; Arya, Gajra; Narkewicz, Michael R.; Sokol, Ronald J.; Karrer, Frederick; Mark, Cara; Orban-Eller, Kathy; Humar, Abhi; Durand, Brenda; Studenski, Leslie; Rand, Elizabeth; Anderer, Kathleen; Mazariegos, George; Chien, Nydia; Seward, Lynn; Atkison, Paul; Roden, Jay; Mittal, Naveen; Cutright, Lisa; Telega, Grzegorz; Lerret, Stacee; Alonso, Estelle M.; Lokar, Joan; Kelly, Susan; Neighbors, Katie; Andrews, Walter S.; Daniel, James; Fioravanti, Vicki; Tendick, Angela; Lindblad, Anne S.; Anand, Ravinder; Song, Changhong; Martz, Karen; Mitchell, Jeff; Fraser, Gladys; Hornbeak, Nicole; Patel, Nirali; He, Jianghang; Fecteau, Annie; Ng, Vicky Lee; De Angelis, Maria; Benidir, Andreanne; Schwarz, Kathleen; Colombani, Paul; Alford, May Kay; Felix, Michelle; Jurao, Robert; Eason, James; Eshun, John; Powell, Sandra L.; Freese, Deborah; Weckwerth, Jody; Greseth, Jean; Young, Lori; Fisher, Robert; Akyeampong, Michael; So, Samuel; Berquist, William; Castillo, Marcia; Bula, Annalie; Emre, Sukru; Shneider, Benjamin; Kerkar, Nanda; Cuellar, Salvador; Karpen, Saul; Mayo, Jaymee; Goss, John; Fishman, Douglas; McLin, Val; Carter, Beth; O'Mahony, Christine; Aloia, Thomas; Garner, Donna; Gilmour, Susan; Dodd, Bernadette; Kneteman, Norman; McDiarmid, Sue; Fiest, Susan; Lobritto, Steven; Smith, Lesley J; Harren, Patricia; Maseda, Kristin; Alvarez, Fernando; Martin, Steven; Viau, Carol; Shepherd, Ross; Lowell, Jeffrey; Nadler, Michelle; Lavine, Joel; Khanna, Ajai; Clawson, Rosemarie; Lopez, James; Magee, John; Shieck, Vicky; Fair, Jeffrey; Lichtman, Steven; Andreoni, Ken; Prinzhorn, Joanne; Buchholz, Valorie; Horslen, Simon; Young, Melissa; Halff, Glenn; Wallace, Stacey; Tector, Joseph; Lim, Joel; Molleston, Jean; Pearson, Jean; Soriano, Humberto; Falkenstein, Kathleen; Tzakis, Andreas; Kato, Tomoaki; Weppler, Debbie; Cooper, Lisa; Gonzalez, Monica; Santiago, Alma; Kalayoglu, Munci; D'Alessandro, Anthony; Erickson, Nissa; Judo, Robert; Knechtle, Stuart; Spaith, Elizabeth; Gonzalez-Peralta, Regino; Hodik, Marcia; McCracken, Stacia; Rosenthal, Philip; Filipowski, Danusia; Book, Linda; O'Gorman, Molly; Kawai, Cynthia K.; Bruschke, Lacey; Kraus, Jennifer; Langnas, Alan; Antonson, Dean; Botha, Jean; Grant, Wendy; Sudan, Debra; Andersen, Debb; Fleckten, Beverly; Seipel, Kris; Millis, J. Michael; Boone, Patricia; Desai, Dev M.; Javis, Sherri; Abt, Peter; Shisler, Tomi; Mack, Cindy.
In: American Journal of Transplantation, Vol. 7, No. 9, 01.09.2007, p. 2165-2171.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Late graft loss or death in pediatric liver transplantation
T2 - an analysis of the SPLIT database
AU - Soltys, K. A.
AU - Mazariegos, G. V.
AU - Squires, R. H.
AU - Sindhi, R. K.
AU - Anand, R.
AU - Dunn, Stephen
AU - Manendez, Jerome
AU - Flynn, Louise
AU - Jonas, Maureen
AU - Krawczuk, Laura
AU - Christoff, Marielle
AU - Kane, Robert
AU - Solomon, Harvey
AU - Phillips, Erin
AU - Ferrer, Laurie
AU - Heffron, Thomas
AU - DePaolo, Jill
AU - Pillen, Todd
AU - Davis, Laurel
AU - Bucuvalas, John
AU - Ryckman, Fred
AU - Hawkins, Andre
AU - Arya, Gajra
AU - Narkewicz, Michael R.
AU - Sokol, Ronald J.
AU - Karrer, Frederick
AU - Mark, Cara
AU - Orban-Eller, Kathy
AU - Humar, Abhi
AU - Durand, Brenda
AU - Studenski, Leslie
AU - Rand, Elizabeth
AU - Anderer, Kathleen
AU - Mazariegos, George
AU - Chien, Nydia
AU - Seward, Lynn
AU - Atkison, Paul
AU - Roden, Jay
AU - Mittal, Naveen
AU - Cutright, Lisa
AU - Telega, Grzegorz
AU - Lerret, Stacee
AU - Alonso, Estelle M.
AU - Lokar, Joan
AU - Kelly, Susan
AU - Neighbors, Katie
AU - Andrews, Walter S.
AU - Daniel, James
AU - Fioravanti, Vicki
AU - Tendick, Angela
AU - Lindblad, Anne S.
AU - Anand, Ravinder
AU - Song, Changhong
AU - Martz, Karen
AU - Mitchell, Jeff
AU - Fraser, Gladys
AU - Hornbeak, Nicole
AU - Patel, Nirali
AU - He, Jianghang
AU - Fecteau, Annie
AU - Ng, Vicky Lee
AU - De Angelis, Maria
AU - Benidir, Andreanne
AU - Schwarz, Kathleen
AU - Colombani, Paul
AU - Alford, May Kay
AU - Felix, Michelle
AU - Jurao, Robert
AU - Eason, James
AU - Eshun, John
AU - Powell, Sandra L.
AU - Freese, Deborah
AU - Weckwerth, Jody
AU - Greseth, Jean
AU - Young, Lori
AU - Fisher, Robert
AU - Akyeampong, Michael
AU - So, Samuel
AU - Berquist, William
AU - Castillo, Marcia
AU - Bula, Annalie
AU - Emre, Sukru
AU - Shneider, Benjamin
AU - Kerkar, Nanda
AU - Cuellar, Salvador
AU - Karpen, Saul
AU - Mayo, Jaymee
AU - Goss, John
AU - Fishman, Douglas
AU - McLin, Val
AU - Carter, Beth
AU - O'Mahony, Christine
AU - Aloia, Thomas
AU - Garner, Donna
AU - Gilmour, Susan
AU - Dodd, Bernadette
AU - Kneteman, Norman
AU - McDiarmid, Sue
AU - Fiest, Susan
AU - Lobritto, Steven
AU - Smith, Lesley J
AU - Harren, Patricia
AU - Maseda, Kristin
AU - Alvarez, Fernando
AU - Martin, Steven
AU - Viau, Carol
AU - Shepherd, Ross
AU - Lowell, Jeffrey
AU - Nadler, Michelle
AU - Lavine, Joel
AU - Khanna, Ajai
AU - Clawson, Rosemarie
AU - Lopez, James
AU - Magee, John
AU - Shieck, Vicky
AU - Fair, Jeffrey
AU - Lichtman, Steven
AU - Andreoni, Ken
AU - Prinzhorn, Joanne
AU - Buchholz, Valorie
AU - Horslen, Simon
AU - Young, Melissa
AU - Halff, Glenn
AU - Wallace, Stacey
AU - Tector, Joseph
AU - Lim, Joel
AU - Molleston, Jean
AU - Pearson, Jean
AU - Soriano, Humberto
AU - Falkenstein, Kathleen
AU - Tzakis, Andreas
AU - Kato, Tomoaki
AU - Weppler, Debbie
AU - Cooper, Lisa
AU - Gonzalez, Monica
AU - Santiago, Alma
AU - Kalayoglu, Munci
AU - D'Alessandro, Anthony
AU - Erickson, Nissa
AU - Judo, Robert
AU - Knechtle, Stuart
AU - Spaith, Elizabeth
AU - Gonzalez-Peralta, Regino
AU - Hodik, Marcia
AU - McCracken, Stacia
AU - Rosenthal, Philip
AU - Filipowski, Danusia
AU - Book, Linda
AU - O'Gorman, Molly
AU - Kawai, Cynthia K.
AU - Bruschke, Lacey
AU - Kraus, Jennifer
AU - Langnas, Alan
AU - Antonson, Dean
AU - Botha, Jean
AU - Grant, Wendy
AU - Sudan, Debra
AU - Andersen, Debb
AU - Fleckten, Beverly
AU - Seipel, Kris
AU - Millis, J. Michael
AU - Boone, Patricia
AU - Desai, Dev M.
AU - Javis, Sherri
AU - Abt, Peter
AU - Shisler, Tomi
AU - Mack, Cindy
PY - 2007/9/1
Y1 - 2007/9/1
N2 - Late graft loss (LGL) and late mortality (LM) following liver transplantation (LT) in children were analyzed from the studies of pediatric liver transplantation (SPLIT) database. Univariate and multivariate associations between pre- and postoperative factors and LGL and LM in 872 patients alive with their primary allografts 1 year after LT were reviewed. Thirty-four patients subsequently died (LM) and 35 patients underwent re-LT (LGL). Patients who survive the first posttransplant year had 5-year patient and graft survival rates of 94.2% and 89.2%, respectively. Graft loss after the first year was caused by rejection in 49% of the cases with sequelae of technical complications accounting for an additional 20% of LGL. LT for tumor, steroid resistant rejection, reoperation in the first 30 days and >5 admissions during the first posttransplant year were independently associated with LGL in multivariate analysis. Malignancy, infection, multiple system organ failure and posttransplant lymphoproliferative disease accounted for 61.8% of all late deaths after LT. LT performed for FHF and tumor were associated with LM. Patients who are at or below the mean for weight at the time of transplant were also at an increased risk of dying. Frequent readmission was also found to be associated with LM.
AB - Late graft loss (LGL) and late mortality (LM) following liver transplantation (LT) in children were analyzed from the studies of pediatric liver transplantation (SPLIT) database. Univariate and multivariate associations between pre- and postoperative factors and LGL and LM in 872 patients alive with their primary allografts 1 year after LT were reviewed. Thirty-four patients subsequently died (LM) and 35 patients underwent re-LT (LGL). Patients who survive the first posttransplant year had 5-year patient and graft survival rates of 94.2% and 89.2%, respectively. Graft loss after the first year was caused by rejection in 49% of the cases with sequelae of technical complications accounting for an additional 20% of LGL. LT for tumor, steroid resistant rejection, reoperation in the first 30 days and >5 admissions during the first posttransplant year were independently associated with LGL in multivariate analysis. Malignancy, infection, multiple system organ failure and posttransplant lymphoproliferative disease accounted for 61.8% of all late deaths after LT. LT performed for FHF and tumor were associated with LM. Patients who are at or below the mean for weight at the time of transplant were also at an increased risk of dying. Frequent readmission was also found to be associated with LM.
KW - Immunosuppression
KW - Infection
KW - Long-term outcomes
KW - Malignancy
KW - Patient and graft survival
KW - Pediatric liver transplantation
UR - http://www.scopus.com/inward/record.url?scp=34547838865&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34547838865&partnerID=8YFLogxK
U2 - 10.1111/j.1600-6143.2007.01893.x
DO - 10.1111/j.1600-6143.2007.01893.x
M3 - Article
C2 - 17608834
AN - SCOPUS:34547838865
VL - 7
SP - 2165
EP - 2171
JO - American Journal of Transplantation
JF - American Journal of Transplantation
SN - 1600-6135
IS - 9
ER -