Late development of a malignant fibrous histiocytoma at the site of a giant cell tumor

E. J. Ortiz-Cruz, R. H. Quinn, J. C. Fanburg, A. E. Rosenberg, H. J. Mankin

Research output: Contribution to journalArticle

18 Scopus citations


A case of late development of a high grade malignant fibrous histiocytoma at the site of a previously surgically treated giant cell tumor is reported. The patient initially was treated for a benign giant cell tumor of the lateral condyle of the distal femur by curettage, implant of auto- and allograft bone, but no radiation. Eighteen years later, he noted progressively increasing pain and disability. Radiographs showed some change, but magnetic resonance imaging clearly disclosed a tumor risking at the site and extending outside the bone. After chemotherapy, the tumor was resected and histologically showed no evidence of a recurrent giant cell tumor, only a high grade malignant fibrous histiocytoma.

Original languageEnglish (US)
Pages (from-to)199-204
Number of pages6
JournalClinical orthopaedics and related research
Issue number318
StatePublished - Jan 1 1995
Externally publishedYes


ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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