Lasiodiplodia theobromae as a cause of keratomycoses

G. Rebell, Richard Forster

Research output: Contribution to journalArticle

Abstract

Four cases of human keratitis caused by the tropical fungus Lasiodiplodia theobromae have been encountered in Miami, Florida bringing to 8 the number of cases reported in the world literature. Two of the ulcers were mild. Three patients recovered without severe impairment of vision after topical polyene treatment, but 1 patient with a severe ulcer required therapeutic keratoplasty after 11 days of topical natamycin. Histopathology revealed fungus deep in the cornea, invading Descemet's membrane. L. theobromae appeared to have collagenase activity in vitro. Inoculation of L. theobromae into the corneas of rabbits produced progressive ulcers. The fungus was endemic in Miami on home grown and imported bananas. Polyene antimycotic antibiotics were fungicidal for L. theobromae in vitro. Thiabendazole was effectively fungistatic but varied in fungicidal effect. Clotrimazole and miconazole were only incompletely fungistatic. Of 7 strains of L. theobromae tested, 4 were relatively resistant to 5-fluorocytosine.

Original languageEnglish
Pages (from-to)155-170
Number of pages16
JournalMedical Mycology
Volume14
Issue number2
DOIs
StatePublished - Jan 1 1976

Fingerprint

Ulcer
Polyenes
Fungi
Cornea
Natamycin
Thiabendazole
Descemet Membrane
Clotrimazole
Miconazole
Flucytosine
cornea
Musa
Corneal Transplantation
Keratitis
fungi
Collagenases
vision disorders
natamycin
clotrimazole
miconazole

ASJC Scopus subject areas

  • veterinary(all)
  • Infectious Diseases

Cite this

Lasiodiplodia theobromae as a cause of keratomycoses. / Rebell, G.; Forster, Richard.

In: Medical Mycology, Vol. 14, No. 2, 01.01.1976, p. 155-170.

Research output: Contribution to journalArticle

Rebell, G. ; Forster, Richard. / Lasiodiplodia theobromae as a cause of keratomycoses. In: Medical Mycology. 1976 ; Vol. 14, No. 2. pp. 155-170.
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