Laser therapy for the treatment of Hailey-Hailey disease: A systematic review with focus on carbon dioxide laser resurfacing

L. A. Falto-Aizpurua, R. D. Griffith, M. A. Yazdani Abyaneh, Keyvan Nouri

Research output: Contribution to journalArticle

12 Scopus citations


Benign familial chronic pemphigus, or Hailey-Hailey disease (HHD), is a recurrent bullous dermatitis that tends to have a chronic course with frequent relapses. Long-term treatment options include surgery with skin grafting or dermabrasion. Both are highly invasive and carry significant risks and complications. More recently, 'laser-abrasion' has been described as a less invasive option with a better side-effect profile. In this article, we systematically review the safety and efficacy of carbon dioxide laser therapy as a long-term treatment option for HHD, as well as provide a review of other lasers that have been reported with this goal. A total of 23 patients who had been treated with a carbon dioxide laser were identified. After treatment, 10 patients (43%) had had no recurrence, 10 (43%) had greater than 50% improvement, 2 (8%) had less than 50% improvement and 1 (4%) patient had no improvement at all (follow-up period ranged from 4 to 144 months). Laser parameter variability was wide and adverse effects were minimal, including dyspigmentation and scarring. Reviewed evidence indicates this therapy offers a safe, effective treatment alternative for HHD with minimal risk of side-effects. Larger, well-designed studies are necessary to determine the optimal treatment parameters.

Original languageEnglish (US)
Pages (from-to)1045-1052
Number of pages8
JournalJournal of the European Academy of Dermatology and Venereology
Issue number6
StatePublished - Jun 1 2015


ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this