Laser interstitial thermotherapy (LITT) monitoring using high-resolution digital mammography: Theory and experimental studies

Ahmed M. Minhaj, Fabrice Manns, Peter J. Milne, David B. Denham, Nelson Salas, Izuru Nose, Karsten Damgaard-Iversen, Jean Marie Parel, David S. Robinson

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Laser interstitial thermotherapy (LITT) is a minimally-invasive laser hyperthermia procedure for the treatment of localized tumours. Real-time monitoring of LITT is essential to control the extent of tumour destruction and ensure safe and effective treatments. The feasibility of using high-resolution digital x-ray mammography to monitor LITT of breast cancer was evaluated. Tissue phantoms including polyacrylamide hydrogel and cadaver porcine tissue were heated using a 980 nm diode laser delivered through optical fibres with diffusing tips. Digital images of the tissue phantoms were recorded with a high-resolution digital stereotactic breast biopsy system during heating. The recorded images were processed and analysed to detect heat-induced changes. No changes were detected during heating of the hydrogel. Pixel-by-pixel subtraction of the initial image from images taken during laser heating shows observable thermally-induced changes around the fibre during laser irradiation that correlate with the thermal denaturation zone observed by gross anatomy. These experiments demonstrate that high-resolution digital x-ray mammography can be used to detect heat-induced tissue changes during experimental LITT in fibro-fatty tissue.

Original languageEnglish (US)
Pages (from-to)2987-2999
Number of pages13
JournalPhysics in Medicine and Biology
Volume47
Issue number16
DOIs
StatePublished - Aug 21 2002

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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