Laser Interstitial Thermal Therapy for Mesial Temporal Lobe Epilepsy

Robert T. Wicks, Walter J. Jermakowicz, Jonathan Jagid, Daniel E. Couture, Jon T. Willie, Adrian W. Laxton, Robert E. Gross

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Approximately one-third of patients with epilepsy do not achieve adequate seizure control through medical management alone. Mesial temporal lobe epilepsy (MTLE) is one of the most common forms of medically refractory epilepsy referred for surgical management. Stereotactic laser amygdalohippocampotomy using magnetic resonance-guided laser interstitial thermal therapy (MRg-LITT) is an important emerging therapy for MTLE. Initial published reports support MRg-LITT as a less invasive surgical option with a shorter hospital stay and fewer neurocognitive side effects compared with craniotomy for anterior temporal lobectomy with amygdalohippocampectomy and selective amygdalohippocampectomy. We provide a historical overview of laser interstitial thermal therapy development and the technological advancements that led to the currently available commercial systems. Current applications of MRg-LITT for MTLE, reported outcomes, and technical issues of the surgical procedure are reviewed. Although initial reports indicate that stereotactic laser amygdalohippocampotomy may be a safe and effective therapy for medically refractory MTLE, further research is required to establish its long-term effectiveness and its cost/benefit profile.

ABBREVIATIONS: ATLAH, anterior temporal lobectomy with amygdalohippocampectomyLITT, laser interstitial thermal therapyMRg-LITT, magnetic resonance-guided laser interstitial thermal therapyMTLE, mesial temporal lobe epilepsySAH, selective amygdalohippocampectomySLAH, stereotactic laser amygdalohippocampotomy.

Original languageEnglish (US)
Pages (from-to)S83-S91
JournalNeurosurgery
Volume79
StatePublished - Dec 1 2016

Fingerprint

Temporal Lobe Epilepsy
Lasers
Hot Temperature
Magnetic Resonance Spectroscopy
Anterior Temporal Lobectomy
Therapeutics
Epilepsy
Craniotomy
Temporal Lobe
Cost-Benefit Analysis
Length of Stay
Seizures

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Wicks, R. T., Jermakowicz, W. J., Jagid, J., Couture, D. E., Willie, J. T., Laxton, A. W., & Gross, R. E. (2016). Laser Interstitial Thermal Therapy for Mesial Temporal Lobe Epilepsy. Neurosurgery, 79, S83-S91.

Laser Interstitial Thermal Therapy for Mesial Temporal Lobe Epilepsy. / Wicks, Robert T.; Jermakowicz, Walter J.; Jagid, Jonathan; Couture, Daniel E.; Willie, Jon T.; Laxton, Adrian W.; Gross, Robert E.

In: Neurosurgery, Vol. 79, 01.12.2016, p. S83-S91.

Research output: Contribution to journalArticle

Wicks, RT, Jermakowicz, WJ, Jagid, J, Couture, DE, Willie, JT, Laxton, AW & Gross, RE 2016, 'Laser Interstitial Thermal Therapy for Mesial Temporal Lobe Epilepsy', Neurosurgery, vol. 79, pp. S83-S91.
Wicks RT, Jermakowicz WJ, Jagid J, Couture DE, Willie JT, Laxton AW et al. Laser Interstitial Thermal Therapy for Mesial Temporal Lobe Epilepsy. Neurosurgery. 2016 Dec 1;79:S83-S91.
Wicks, Robert T. ; Jermakowicz, Walter J. ; Jagid, Jonathan ; Couture, Daniel E. ; Willie, Jon T. ; Laxton, Adrian W. ; Gross, Robert E. / Laser Interstitial Thermal Therapy for Mesial Temporal Lobe Epilepsy. In: Neurosurgery. 2016 ; Vol. 79. pp. S83-S91.
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