Laser ablation of newly diagnosed malignant gliomas: A meta-Analysis

Michael E. Ivan, Alireza M. Mohammadi, Nicoleta De Deugd, Joshua Reyes, Gregor Rodriguez, Ashish Shah, Gene H. Barnett, Ricardo J. Komotar

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


BACKGROUND: Magnetic resonance-guided laser-interstitial thermotherapy (MR-LITT) is a minimally invasive technique that shows promise in neuro-oncology because of its superiority in delivering precise minimally invasive thermal energy with minimal collateral damage. OBJECTIVE: In this analysis, we investigate initial data on the use of MR-LITT in the treatment of newly diagnosed high-grade gliomas. METHODS: With the use of the PubMed, OVID, and Google-scholar database systems, a comprehensive search of the English literature was performed. Eighty-five articles were identified plus 1 that is pending publication. Four articles were accounted for in this review, including 25 patients with newly diagnosed high-grade gliomas who underwent MR-LITT treatment. We evaluated safety, progression-free survival, and overall survival. RESULTS: Twenty-five patients with a mean age of 53.8 years underwent LITT treatments. On average, 82.9% of the pretreatment lesion volume was ablated. The average tumor volume treated was 16.5 cm3. The mean follow-up time was 7.6 months. Median overall survival was found to be 14.2 months (range 0.1-23 months). The median progression-free survival was 5.1 months (range 2.4-23 months); however, these data are limited by the relatively short follow-up of the patients reviewed and small sample size of only 25 patients. There was 1 (3.4%) major perioperative complication, which was a central nervous system infection. CONCLUSION: MR-LITT is a promising technology for the treatment of small, yet difficult-to-treat newly diagnosed high-grade gliomas. This study demonstrates that MR-LITT is safe, and future randomized studies are needed to evaluate its role as a treatment adjunct for newly diagnosed high-grade gliomas.

Original languageEnglish (US)
Pages (from-to)S17-S23
JournalClinical neurosurgery
StatePublished - Dec 1 2016


  • Brain tumors
  • Glioblastoma
  • Glioma
  • Laser-interstitial thermotherapy
  • Minimally invasive neurosurgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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