TY - JOUR
T1 - Large animal canine endovascular ischemic stroke models
T2 - A review
AU - Atchaneeyasakul, Kunakorn
AU - Guada, Luis
AU - Ramdas, Kevin
AU - Watanabe, Mitsuyoshi
AU - Bhattacharya, Pallab
AU - Raval, Ami
AU - Yavagal, Dileep R
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Background Stroke is one of the leading causes of death and long-term disability worldwide. Recent exciting developments in the field with endovascular treatments have shown excellent outcomes in acute ischemic stroke. Prior to translating these treatments to human populations, a large-animal ischemic stroke model is needed. With the advent of new technologies in digital subtraction angiography, less invasive endovascular stroke models have been developed. Canines have gyrencephalic brain similar to human brain and accessible neurovascular anatomy for stroke model creation. Canine stroke model can be widely utilized to understand the disease process of stroke and to develop novel treatment. Less invasive endovascular internal carotid emboli injection and coil embolization methods can be used to simulate transient or permanent middle cerebral artery occlusion. Major restriction includes the extensive collateral circulation of canine cerebral arteries that can limit the stroke size. Transient internal carotid artery occlusion can decrease collateral circulation and increase stroke size to some degree. Additional method of manipulating the extent of collateral circulation needs to be studied. Other types of canine stroke models, including vertebral artery occlusion and basilar artery occlusion, can also be accomplished by endovascular thrombi injection. Conclusions We extensively review the literature on endovascular technique of creating canine ischemic stroke models and their application in finding new therapies for ischemic stroke.
AB - Background Stroke is one of the leading causes of death and long-term disability worldwide. Recent exciting developments in the field with endovascular treatments have shown excellent outcomes in acute ischemic stroke. Prior to translating these treatments to human populations, a large-animal ischemic stroke model is needed. With the advent of new technologies in digital subtraction angiography, less invasive endovascular stroke models have been developed. Canines have gyrencephalic brain similar to human brain and accessible neurovascular anatomy for stroke model creation. Canine stroke model can be widely utilized to understand the disease process of stroke and to develop novel treatment. Less invasive endovascular internal carotid emboli injection and coil embolization methods can be used to simulate transient or permanent middle cerebral artery occlusion. Major restriction includes the extensive collateral circulation of canine cerebral arteries that can limit the stroke size. Transient internal carotid artery occlusion can decrease collateral circulation and increase stroke size to some degree. Additional method of manipulating the extent of collateral circulation needs to be studied. Other types of canine stroke models, including vertebral artery occlusion and basilar artery occlusion, can also be accomplished by endovascular thrombi injection. Conclusions We extensively review the literature on endovascular technique of creating canine ischemic stroke models and their application in finding new therapies for ischemic stroke.
KW - Basilar artery occlusion
KW - Canine model
KW - Middle cerebral artery occlusion
KW - Stroke
KW - Vertebral artery occlusion
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U2 - 10.1016/j.brainresbull.2016.07.006
DO - 10.1016/j.brainresbull.2016.07.006
M3 - Review article
C2 - 27496066
AN - SCOPUS:84987933840
VL - 127
SP - 134
EP - 140
JO - Brain Research Bulletin
JF - Brain Research Bulletin
SN - 0361-9230
ER -