Laparoscopic Radical Nephrectomy for Renal Cell Carcinoma

Oncological Outcomes at 10 Years or More

Andre Berger, Ricardo Brandina, Mohamed A. Atalla, Amin S. Herati, Kazumi Kamoi, Monish Aron, Georges Pascal Haber, Robert J. Stein, Mihir M. Desai, Louis R. Kavoussi, Inderbir S. Gill

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Purpose: We present oncological outcomes at a followup of 10 years or greater after laparoscopic radical nephrectomy for cancer. Materials and Methods: Between February 1994 and March 1999 a total of 73 laparoscopic radical nephrectomies were performed by 2 surgeons for pathologically confirmed renal cell carcinoma. Data were obtained from patient charts, radiographic reports, telephone followup and a check of the Social Security Death Index. Results: Mean followup was 11.2 years (range 10 to 15). Each patient completed a minimum 10-year followup. Mean patient age at surgery was 60 years. Mean tumor size on computerized tomography was 5 cm (range 1.7 to 13). Pathological stage was pT1a in 41% of cases, pT1b in 30%, pT2 in 15%, pT3a in 10%, pT3b in 3% and pT4 in 1%. High grade tumors (Fuhrman 3 or greater) were present in 18 cases (28%). A positive surgical margin occurred in 1 case. Actual 10-year overall, cancer specific and recurrence-free survival rates were 65%, 92% and 86%, respectively. Overall, cancer specific and recurrence-free survival rates at 12 years were 35%, 78% and 77%, respectively. At a mean of 67 months 10 patients (14%) had metastatic disease, of whom 8 (11%) died. Conclusions: Long-term oncological outcomes after laparoscopic radical nephrectomy for renal cell carcinoma are excellent and appear comparable to those of open surgery.

Original languageEnglish (US)
Pages (from-to)2172-2176
Number of pages5
JournalJournal of Urology
Volume182
Issue number5
DOIs
StatePublished - Nov 2009
Externally publishedYes

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Nephrectomy
Renal Cell Carcinoma
Neoplasms
Survival Rate
Recurrence
Social Security
Telephone
Tomography

Keywords

  • carcinoma
  • kidney
  • laparoscopy
  • nephrectomy
  • outcome assessment (health care)
  • renal cell

ASJC Scopus subject areas

  • Urology
  • Medicine(all)

Cite this

Berger, A., Brandina, R., Atalla, M. A., Herati, A. S., Kamoi, K., Aron, M., ... Gill, I. S. (2009). Laparoscopic Radical Nephrectomy for Renal Cell Carcinoma: Oncological Outcomes at 10 Years or More. Journal of Urology, 182(5), 2172-2176. https://doi.org/10.1016/j.juro.2009.07.047

Laparoscopic Radical Nephrectomy for Renal Cell Carcinoma : Oncological Outcomes at 10 Years or More. / Berger, Andre; Brandina, Ricardo; Atalla, Mohamed A.; Herati, Amin S.; Kamoi, Kazumi; Aron, Monish; Haber, Georges Pascal; Stein, Robert J.; Desai, Mihir M.; Kavoussi, Louis R.; Gill, Inderbir S.

In: Journal of Urology, Vol. 182, No. 5, 11.2009, p. 2172-2176.

Research output: Contribution to journalArticle

Berger, A, Brandina, R, Atalla, MA, Herati, AS, Kamoi, K, Aron, M, Haber, GP, Stein, RJ, Desai, MM, Kavoussi, LR & Gill, IS 2009, 'Laparoscopic Radical Nephrectomy for Renal Cell Carcinoma: Oncological Outcomes at 10 Years or More', Journal of Urology, vol. 182, no. 5, pp. 2172-2176. https://doi.org/10.1016/j.juro.2009.07.047
Berger, Andre ; Brandina, Ricardo ; Atalla, Mohamed A. ; Herati, Amin S. ; Kamoi, Kazumi ; Aron, Monish ; Haber, Georges Pascal ; Stein, Robert J. ; Desai, Mihir M. ; Kavoussi, Louis R. ; Gill, Inderbir S. / Laparoscopic Radical Nephrectomy for Renal Cell Carcinoma : Oncological Outcomes at 10 Years or More. In: Journal of Urology. 2009 ; Vol. 182, No. 5. pp. 2172-2176.
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abstract = "Purpose: We present oncological outcomes at a followup of 10 years or greater after laparoscopic radical nephrectomy for cancer. Materials and Methods: Between February 1994 and March 1999 a total of 73 laparoscopic radical nephrectomies were performed by 2 surgeons for pathologically confirmed renal cell carcinoma. Data were obtained from patient charts, radiographic reports, telephone followup and a check of the Social Security Death Index. Results: Mean followup was 11.2 years (range 10 to 15). Each patient completed a minimum 10-year followup. Mean patient age at surgery was 60 years. Mean tumor size on computerized tomography was 5 cm (range 1.7 to 13). Pathological stage was pT1a in 41{\%} of cases, pT1b in 30{\%}, pT2 in 15{\%}, pT3a in 10{\%}, pT3b in 3{\%} and pT4 in 1{\%}. High grade tumors (Fuhrman 3 or greater) were present in 18 cases (28{\%}). A positive surgical margin occurred in 1 case. Actual 10-year overall, cancer specific and recurrence-free survival rates were 65{\%}, 92{\%} and 86{\%}, respectively. Overall, cancer specific and recurrence-free survival rates at 12 years were 35{\%}, 78{\%} and 77{\%}, respectively. At a mean of 67 months 10 patients (14{\%}) had metastatic disease, of whom 8 (11{\%}) died. Conclusions: Long-term oncological outcomes after laparoscopic radical nephrectomy for renal cell carcinoma are excellent and appear comparable to those of open surgery.",
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AU - Atalla, Mohamed A.

AU - Herati, Amin S.

AU - Kamoi, Kazumi

AU - Aron, Monish

AU - Haber, Georges Pascal

AU - Stein, Robert J.

AU - Desai, Mihir M.

AU - Kavoussi, Louis R.

AU - Gill, Inderbir S.

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N2 - Purpose: We present oncological outcomes at a followup of 10 years or greater after laparoscopic radical nephrectomy for cancer. Materials and Methods: Between February 1994 and March 1999 a total of 73 laparoscopic radical nephrectomies were performed by 2 surgeons for pathologically confirmed renal cell carcinoma. Data were obtained from patient charts, radiographic reports, telephone followup and a check of the Social Security Death Index. Results: Mean followup was 11.2 years (range 10 to 15). Each patient completed a minimum 10-year followup. Mean patient age at surgery was 60 years. Mean tumor size on computerized tomography was 5 cm (range 1.7 to 13). Pathological stage was pT1a in 41% of cases, pT1b in 30%, pT2 in 15%, pT3a in 10%, pT3b in 3% and pT4 in 1%. High grade tumors (Fuhrman 3 or greater) were present in 18 cases (28%). A positive surgical margin occurred in 1 case. Actual 10-year overall, cancer specific and recurrence-free survival rates were 65%, 92% and 86%, respectively. Overall, cancer specific and recurrence-free survival rates at 12 years were 35%, 78% and 77%, respectively. At a mean of 67 months 10 patients (14%) had metastatic disease, of whom 8 (11%) died. Conclusions: Long-term oncological outcomes after laparoscopic radical nephrectomy for renal cell carcinoma are excellent and appear comparable to those of open surgery.

AB - Purpose: We present oncological outcomes at a followup of 10 years or greater after laparoscopic radical nephrectomy for cancer. Materials and Methods: Between February 1994 and March 1999 a total of 73 laparoscopic radical nephrectomies were performed by 2 surgeons for pathologically confirmed renal cell carcinoma. Data were obtained from patient charts, radiographic reports, telephone followup and a check of the Social Security Death Index. Results: Mean followup was 11.2 years (range 10 to 15). Each patient completed a minimum 10-year followup. Mean patient age at surgery was 60 years. Mean tumor size on computerized tomography was 5 cm (range 1.7 to 13). Pathological stage was pT1a in 41% of cases, pT1b in 30%, pT2 in 15%, pT3a in 10%, pT3b in 3% and pT4 in 1%. High grade tumors (Fuhrman 3 or greater) were present in 18 cases (28%). A positive surgical margin occurred in 1 case. Actual 10-year overall, cancer specific and recurrence-free survival rates were 65%, 92% and 86%, respectively. Overall, cancer specific and recurrence-free survival rates at 12 years were 35%, 78% and 77%, respectively. At a mean of 67 months 10 patients (14%) had metastatic disease, of whom 8 (11%) died. Conclusions: Long-term oncological outcomes after laparoscopic radical nephrectomy for renal cell carcinoma are excellent and appear comparable to those of open surgery.

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