Laparoscopic and histologic findings in patients with the human immunodeficiency virus

Lennox J. Jeffers, Isaac Alzate, Humberto Aguilar, K. Rajender Reddy, Victor Idrovo, Hugo Cheinquer, Fuad A. Hasan, Talley Parker, Carlos Montero, Gordon Dickinson, Eugene R. Schiff

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Hepatic dysfunction frequently develops in patients infected with the human immunodeficiency virus (HIV). This retrospective study was undertaken to determine the laparoscopic and histologic findings in a group of HIV- seropositive patients with or without the acquired immune deficiency syndrome (AIDS). Fifty-four patients, 44 with AIDS and 10 HIV-positive, underwent laparoscopic examination and visually guided biopsies for the assessment of clinical or biochemical evidence of liver injury. Significant abnormalities were detected in 31/44 (70%) AIDS patients and 3/10 (30%) HIV-positive patients. Overall, specific laparoscopic findings were described in 25/54 (46%). The most common findings were peritoneal involvement, massive intra- abdominal adhesions, focal lesions of the liver or spleen, and diffuse nodularity of the liver; these were usually related to opportunistic infections or neoplasms such as non-Hodgkin's lymphomas and Kaposi's sarcoma. No procedure-related deaths occurred. Laparoscopy is a safe and accurate method to detect underlying disease in a selected population of HIV- seropositive patients.

Original languageEnglish (US)
Pages (from-to)160-164
Number of pages5
JournalGastrointestinal endoscopy
Issue number2
StatePublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology


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