Langerhans' cell histiocytosis of the head and neck in children

Simon I Angeli, J. Alcalde, H. T. Hoffman, R. J H Smith

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

This is a retrospective analysis of a 29-year institutional experience with Langerhans' cell histiocytosis (LCH) in children. Cases of LCH were categorized by disease extent into three groups: group 1, with a solitary focus of LCH; group 2, with multiple non-vital organ foci; and group 3, with vital organ disease. Sixteen patients averaging 7.3 years of age and with 11.0 years of follow-up presented in group 1. One child experienced a spontaneous remission; all other children responded to local treatment. The skull was the most common site of involvement. Eight children averaging 4.6 years in age and with 8.0 years of follow-up presented in group 2; 3 children had diabetes insipidus. Treatment included radical surgery, radiotherapy, and chemotherapy; however, disease persisted in all patients. Iatrogenic complications were a significant cause of morbidity and mortality. Only 1 patient, 1 year of age, presented with lung and liver involvement (group 3). He died after a fulminant course. Current recommendations for diagnosis, evaluation, and treatment of LCH are discussed.

Original languageEnglish
Pages (from-to)173-180
Number of pages8
JournalAnnals of Otology, Rhinology and Laryngology
Volume104
Issue number3
StatePublished - Jan 1 1995
Externally publishedYes

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Langerhans Cell Histiocytosis
Neck
Head
Spontaneous Remission
Diabetes Insipidus
Skull
Radiotherapy
Therapeutics
Morbidity
Drug Therapy
Lung
Mortality
Liver

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Langerhans' cell histiocytosis of the head and neck in children. / Angeli, Simon I; Alcalde, J.; Hoffman, H. T.; Smith, R. J H.

In: Annals of Otology, Rhinology and Laryngology, Vol. 104, No. 3, 01.01.1995, p. 173-180.

Research output: Contribution to journalArticle

Angeli, SI, Alcalde, J, Hoffman, HT & Smith, RJH 1995, 'Langerhans' cell histiocytosis of the head and neck in children', Annals of Otology, Rhinology and Laryngology, vol. 104, no. 3, pp. 173-180.
Angeli, Simon I ; Alcalde, J. ; Hoffman, H. T. ; Smith, R. J H. / Langerhans' cell histiocytosis of the head and neck in children. In: Annals of Otology, Rhinology and Laryngology. 1995 ; Vol. 104, No. 3. pp. 173-180.
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