Langerhans' cell histiocytosis in patients older than 21 years

Richard B. Islinger, Timothy R. Kuklo, Brett D. Owens, Patrick J. Horan, Theodore J. Choma, Mark D. Murphey, H. Thomas Temple

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


In this retrospective review of 541 patients with Langerhans' cell histiocytosis, 211 (39%) patients were older than 21 years of age, whereas 330 (61%) were younger than 21 years of age. The adult patients had a mean age of 32 years (range, 21-69 years) with 159 (75%) men and 52 (25%) women, whereas the pediatric patients consisted of 176 (55 %) boys and 144 (45 %) girls. This male predominance in adults was statistically significant. Three adults had the Hand-Schuller-Christian variant, whereas the remaining adults (208) had eosinophilic granuloma. The rib accounted for 25% of the adult lesions and only 8% of the pediatric lesions. Spine involvement was less common in the adult group (3% versus 10%) and was predominantly thoracic. The adult patients had 40 (77%) diaphyseal lesions, 12 (23%) metaphyseal lesions, and no epiphyseal lesions. The pediatric patients had 75 (54%) diaphyseal, 59 (42%) metaphyseal, and five (4%) epiphyseal lesions. Radiographic evaluation revealed similar margin and matrix patterns in both groups, with a geographic lesion without sclerotic borders being the most common pattern. Langerhans' cell histiocytosis is considered a pediatric disease. However, this study showed a significant number (39%) of patients older than 21 years of age with this condition.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalClinical orthopaedics and related research
Issue number379
StatePublished - Jan 1 2000

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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