Langerhans' cell histiocytosis in patients older than 21 years

Richard B. Islinger, Timothy R. Kuklo, Brett D. Owens, Patrick J. Horan, Theodore J. Choma, Mark D. Murphey, H. Thomas Temple

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Abstract

In this retrospective review of 541 patients with Langerhans' cell histiocytosis, 211 (39%) patients were older than 21 years of age, whereas 330 (61%) were younger than 21 years of age. The adult patients had a mean age of 32 years (range, 21-69 years) with 159 (75%) men and 52 (25%) women, whereas the pediatric patients consisted of 176 (55 %) boys and 144 (45 %) girls. This male predominance in adults was statistically significant. Three adults had the Hand-Schuller-Christian variant, whereas the remaining adults (208) had eosinophilic granuloma. The rib accounted for 25% of the adult lesions and only 8% of the pediatric lesions. Spine involvement was less common in the adult group (3% versus 10%) and was predominantly thoracic. The adult patients had 40 (77%) diaphyseal lesions, 12 (23%) metaphyseal lesions, and no epiphyseal lesions. The pediatric patients had 75 (54%) diaphyseal, 59 (42%) metaphyseal, and five (4%) epiphyseal lesions. Radiographic evaluation revealed similar margin and matrix patterns in both groups, with a geographic lesion without sclerotic borders being the most common pattern. Langerhans' cell histiocytosis is considered a pediatric disease. However, this study showed a significant number (39%) of patients older than 21 years of age with this condition.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalClinical orthopaedics and related research
Issue number379
DOIs
StatePublished - Jan 1 2000

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ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Islinger, R. B., Kuklo, T. R., Owens, B. D., Horan, P. J., Choma, T. J., Murphey, M. D., & Temple, H. T. (2000). Langerhans' cell histiocytosis in patients older than 21 years. Clinical orthopaedics and related research, (379), 231-235. https://doi.org/10.1097/00003086-200010000-00027