Landmark Series: Importance of Pancreatic Resection Margins

Mihir M. Shah, Jashodeep Datta, Nipun B. Merchant, David A. Kooby

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


An important goal of cancer surgery is to achieve negative surgical margins and remove all disease completely. For pancreatic neoplasms, microscopic margins may remain positive despite gross removal of the palpable mass, and surgeons must then consider extending resection, even to the point of completion pancreatectomy, an option that renders the patient with significant adverse effects related to exocrine and endocrine insufficiency. Counterintuitively, extending resection to ensure clear margins may not improve patient outcome. Furthermore, the goal of improving survival by extending the resection may not be achieved, as an initial positive margin may indicate more aggressive underlying tumor biology. There is a growing body of literature on this topic, and this landmark series review will examine the key publications that guide our management for resection of pancreatic ductal adenocarcinoma, intraductal papillary mucinous neoplasms, and pancreatic neuroendocrine tumors.

Original languageEnglish (US)
Pages (from-to)1542-1550
Number of pages9
JournalAnnals of Surgical Oncology
Issue number3
StatePublished - Mar 2022
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Oncology


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