Lactate administration attenuates cognitive deficits following traumatic brain injury

Ann C. Rice, Robert Zsoldos, Tao Chen, Margaret S. Wilson, B. Alessandri, Robert J. Hamm, M. Ross Bullock

Research output: Contribution to journalArticle

79 Scopus citations


Moderately head injured patients often suffer long term neurological sequelae. There is no therapy for brain trauma and current treatments aim only to minimize secondary damage. These secondary effects are often triggered by the inability to re-establish ionic homeostasis after injury, due to large energy demands. Recent reports have demonstrated that neurons are capable of utilizing lactate as an energy source, thus this report examines the usefulness of lactate administration in the attenuation of behavioural deficits following a moderate brain injury. Lactate infusion (i.v.) was started 30 min after lateral fluid percussion injury and continued for 3 h. Cognitive deficits were determined using the Morris water maze. Lactate infused injured animals demonstrated significantly less cognitive deficits than saline infused injured animals. Thus, lactate infusion attenuated the cognitive deficits normally observed in this model, and therefore may provide moderately head injured patients with a treatment to help ameliorate the sequelae.

Original languageEnglish (US)
Pages (from-to)156-159
Number of pages4
JournalBrain Research
Issue number1-2
StatePublished - Feb 22 2002


  • Lateral fluid percussion injury
  • Morris water maze

ASJC Scopus subject areas

  • Neuroscience(all)

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    Rice, A. C., Zsoldos, R., Chen, T., Wilson, M. S., Alessandri, B., Hamm, R. J., & Ross Bullock, M. (2002). Lactate administration attenuates cognitive deficits following traumatic brain injury. Brain Research, 928(1-2), 156-159.