Lack of reduction in body fat after treatment with insulin-like growth factor-I in two children with growth hormone gene deletions

Ivo J.P. Arnhold, S. B. Oliveira, M. G.F. Osorio, A. J.F. Carrilho, W. Nicolau, A. C. Bianco, B. B. Mendonca

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Two patients with growth hormone (GH) gene deletions were treated with recombinant insulin-like growth factor-I (IGF-I) (80-240 (μg/kg/day) and the effects on bone mass and body composition were compared to administration of GH (0.075 U/kg/day) to 8 patients with idiopathic GH deficiency. Bone mass and body composition were measured by dual photon X-ray absorptiometry (DEXA) before and 3 and 6 months after treatment with GH or IGF-I. Similar increases in growth velocities were observed after GH and IGF-I treatment. Treatment with GH resulted in prompt and significant reduction in body fat percentage (basal, 3 and 6 months: 22±10, 17±9, and 16±9%) whereas body fat percentage remained unchanged after IGF-I therapy (basal, 3 and 6 months: 49, 52 and 48% in patient 1 and 45, 42 and 43% in patient 2, respectively). Fat percentage remained elevated after 18 months of IGF-I treatment in patients 1 (51%) and 2 (44%), respectively. Lean mass and bone mineral content increased with GH and IGF-I therapies. We conclude that reduction of body fat measured by DEXA, observed after administration of GH but not after IGF-I treatment in these children with GH deficiency, suggests that the GH effect on body fat mass is not mediated by circulating IGF-I. (C)2000, Editrice Kurtis.

Original languageEnglish (US)
Pages (from-to)258-262
Number of pages5
JournalJournal of endocrinological investigation
Volume23
Issue number4
DOIs
StatePublished - Jan 1 2000

Keywords

  • Body composition
  • Body fat
  • GH deficiency
  • GH gene deletions
  • IGF-I treatment

ASJC Scopus subject areas

  • Endocrinology

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    Arnhold, I. J. P., Oliveira, S. B., Osorio, M. G. F., Carrilho, A. J. F., Nicolau, W., Bianco, A. C., & Mendonca, B. B. (2000). Lack of reduction in body fat after treatment with insulin-like growth factor-I in two children with growth hormone gene deletions. Journal of endocrinological investigation, 23(4), 258-262. https://doi.org/10.1007/BF03343719