Lack of protection by pyridoxine or hydrazine pretreatment against monosodium L-glutamate-induced seizures

Charles B. Nemeroff, Francis D. Crisley

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Pretreatment of rats with hydrazine (100 mg/kg), a compound which raises brain gamma-aminobutyric acid (GABA) 175 percent in 12 hr was not able to prevent the occurrence of seizures induced by monosodium L-glutamate (MSG). Pyridoxine (50 mg/kg), the cofactor essential in the conversion of glutamate to GABA, also failed to prevent convulsions induced by parenteral MSG administration. It is concluded that the mechanism of action of MSG-induced seizures is neither by decreasing brain GABA levels or interfering with the pyridoxine cofactor.

Original languageEnglish (US)
Pages (from-to)927-929
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume3
Issue number5
DOIs
StatePublished - Jan 1 1975
Externally publishedYes

Keywords

  • GABA
  • Hydrazine
  • Monosodium L-glutamate
  • Pyridoxine
  • Seizures

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Fingerprint Dive into the research topics of 'Lack of protection by pyridoxine or hydrazine pretreatment against monosodium L-glutamate-induced seizures'. Together they form a unique fingerprint.

  • Cite this