Lack of prolactin release-inhibiting activity in synthetic LH-releasing hormone

L. Debeljuk, A. Arimura, A. V. Schally

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

In order to test if LH-RH also displays prolactin release-inhibiting activity, synthetic LH-RH was injected into intact diestrous rats and ovariectomized, estrogen-progesterone treated rats. Both groups of rats were pretreated with reserpine in order to increase serum prolactin levels. LH and prolactin were determined by radioimmunoassay In spite of the fact that LH-RH brought about significant serum LH increase in both groups, no prolactin inhibition was seen. These results indicate that under the conditions of this investigation, LH-RH does not seem to display any prolactin release-inhibiting activity.

Original languageEnglish (US)
Pages (from-to)918-920
Number of pages3
JournalJournal of Clinical Endocrinology and Metabolism
Volume35
Issue number6
DOIs
StatePublished - Dec 1972
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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