Lack of generation of killer cells in the mixed lymphocyte reaction between mitogen-stimulated and unstimulated autologous lymphocytes

P. Katz, B. F. Haynes, A. S. Fauci

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The present study has demonstrated that the Con A-activated cell mediated autologous mixed lymphocyte reaction (MLR) is not associated with the generation of cytotoxic effector cells that kill autologous targets. Thus, the suppression of antibody production of PWM stimulated lymphocytes by autologous Con A-activated suppressor cells cannot be explained by detectable cytotoxicity. We have further demonstrated that the stimulator cell in this system is a nonadherent non-T cell.

Original languageEnglish (US)
Pages (from-to)1998-2001
Number of pages4
JournalJournal of Immunology
Volume121
Issue number5
StatePublished - Dec 1 1978

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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