Abstract
The present study has demonstrated that the Con A-activated cell mediated autologous mixed lymphocyte reaction (MLR) is not associated with the generation of cytotoxic effector cells that kill autologous targets. Thus, the suppression of antibody production of PWM stimulated lymphocytes by autologous Con A-activated suppressor cells cannot be explained by detectable cytotoxicity. We have further demonstrated that the stimulator cell in this system is a nonadherent non-T cell.
| Original language | English |
|---|---|
| Pages (from-to) | 1998-2001 |
| Number of pages | 4 |
| Journal | Journal of Immunology |
| Volume | 121 |
| Issue number | 5 |
| State | Published - Dec 1 1978 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
Cite this
Lack of generation of killer cells in the mixed lymphocyte reaction between mitogen-stimulated and unstimulated autologous lymphocytes. / Katz, P.; Haynes, B. F.; Fauci, A. S.
In: Journal of Immunology, Vol. 121, No. 5, 01.12.1978, p. 1998-2001.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Lack of generation of killer cells in the mixed lymphocyte reaction between mitogen-stimulated and unstimulated autologous lymphocytes
AU - Katz, P.
AU - Haynes, B. F.
AU - Fauci, A. S.
PY - 1978/12/1
Y1 - 1978/12/1
N2 - The present study has demonstrated that the Con A-activated cell mediated autologous mixed lymphocyte reaction (MLR) is not associated with the generation of cytotoxic effector cells that kill autologous targets. Thus, the suppression of antibody production of PWM stimulated lymphocytes by autologous Con A-activated suppressor cells cannot be explained by detectable cytotoxicity. We have further demonstrated that the stimulator cell in this system is a nonadherent non-T cell.
AB - The present study has demonstrated that the Con A-activated cell mediated autologous mixed lymphocyte reaction (MLR) is not associated with the generation of cytotoxic effector cells that kill autologous targets. Thus, the suppression of antibody production of PWM stimulated lymphocytes by autologous Con A-activated suppressor cells cannot be explained by detectable cytotoxicity. We have further demonstrated that the stimulator cell in this system is a nonadherent non-T cell.
UR - http://www.scopus.com/inward/record.url?scp=0018080592&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018080592&partnerID=8YFLogxK
M3 - Article
VL - 121
SP - 1998
EP - 2001
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 5
ER -