Lack of efficacy of vinblastine and cisplatin in patients with progressive small cell carcinoma of the lung

S. B. Newman, J. D. Bitran, P. C. Hoffman, V. Raghaven, T. R. DeMeester, H. M. Golomb

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Abstract

Twenty patients with small cell carcinoma of the lung resistant to primary therapy, or relapsing after an objective response to initial treatment, were treated with vinblastine plus high-dose cisplatin chemotherapy. One patient achieved a partial remission lasting 4 months, while 19 patients had no objective response to this regimen. The median survival from the time of disease progression to death was 2.5 months (range, 1-7), with an overall median survival of 13 months (range, 5-31; diagnosis to death). In our patients, vinblastine plus cisplatin given as salvage therapy did not produce a significant response rate or survival prolongation.

Original languageEnglish (US)
Pages (from-to)831-832
Number of pages2
JournalCancer treatment reports
Volume67
Issue number9
StatePublished - Nov 26 1983

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Newman, S. B., Bitran, J. D., Hoffman, P. C., Raghaven, V., DeMeester, T. R., & Golomb, H. M. (1983). Lack of efficacy of vinblastine and cisplatin in patients with progressive small cell carcinoma of the lung. Cancer treatment reports, 67(9), 831-832.