Lack of efficacy of tacrolimus ointment 0.1% for treatment of hemodialysis-related pruritus: a randomized, double-blind, vehicle-controlled study.

Maria I. Duque, Gil Yosipovitch, Alan B. Fleischer, Joy Willard, Barry I. Freedman

Research output: Contribution to journalArticle

55 Scopus citations

Abstract

Pruritus is a common and disabling symptom for patients undergoing hemodialysis. Many topical and systemic treatments have been used for uremic pruritus, mostly in anecdotal reports. A recent case series demonstrated that topical tacrolimus ointment 0.03% had a significant antipruritic effect for patients with uremia. In an attempt to confirm these findings, we conducted a randomized, double-blind, vehicle-controlled study to assess the efficacy of tacrolimus ointment 0.1% for the treatment of hemodialysis-related pruritus. The results of this study do not demonstrate that tacrolimus ointment 0.1% is more effective than vehicle in relieving uremic pruritus.

Original languageEnglish (US)
Pages (from-to)519-521
Number of pages3
JournalJournal of the American Academy of Dermatology
Volume52
Issue number3 Pt 1
StatePublished - Mar 2005
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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