Abstract
Ten patients with insulin-dependent diabetes mellitus underwent a program of intensification of therapy that resulted in marked improvement in glycemic control. C-peptide secretion in response to a test meal and to an intravenous glucagon challenge was used to assess pancreatic B-cell function in terms of residual endogenous insulin secretion. Patients, who had diabetes for a mean (±SEM) of 8.4 ± 1.9 yr, had minimal or no C-peptide response at baseline evaluation. C-peptide responses remained unchanged when reassessed after 2, 4, and 6 mo of improved glycemic control.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 334-336 |
| Number of pages | 3 |
| Journal | Diabetes care |
| Volume | 5 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1982 |
ASJC Scopus subject areas
- Internal Medicine
- Endocrinology, Diabetes and Metabolism
- Advanced and Specialized Nursing
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Seigler, D., Reeves, M. L., & Skyler, J. S. (1982). Lack of effect of improved glycemic control on C-peptide secretion in patients without residual B-cell function. Diabetes care, 5(3), 334-336. https://doi.org/10.2337/diacare.5.3.334