Lack of effect of improved glycemic control on C-peptide secretion in patients without residual B-cell function

D. Seigler; M. L. Reeves; J. S. Skyler

doi:10.2337/diacare.5.3.334

Lack of effect of improved glycemic control on C-peptide secretion in patients without residual B-cell function

D. Seigler, M. L. Reeves, J. S. Skyler

Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Ten patients with insulin-dependent diabetes mellitus underwent a program of intensification of therapy that resulted in marked improvement in glycemic control. C-peptide secretion in response to a test meal and to an intravenous glucagon challenge was used to assess pancreatic B-cell function in terms of residual endogenous insulin secretion. Patients, who had diabetes for a mean (±SEM) of 8.4 ± 1.9 yr, had minimal or no C-peptide response at baseline evaluation. C-peptide responses remained unchanged when reassessed after 2, 4, and 6 mo of improved glycemic control.

Original language	English (US)
Pages (from-to)	334-336
Number of pages	3
Journal	Diabetes care
Volume	5
Issue number	3
DOIs	https://doi.org/10.2337/diacare.5.3.334
State	Published - Jan 1 1982

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Advanced and Specialized Nursing

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10.2337/diacare.5.3.334

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Lack of effect of improved glycemic control on C-peptide secretion in patients without residual B-cell function

Abstract

ASJC Scopus subject areas

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