Lack of effect of improved glycemic control on C-peptide secretion in patients without residual B-cell function

D. Seigler, M. L. Reeves, J. S. Skyler

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Ten patients with insulin-dependent diabetes mellitus underwent a program of intensification of therapy that resulted in marked improvement in glycemic control. C-peptide secretion in response to a test meal and to an intravenous glucagon challenge was used to assess pancreatic B-cell function in terms of residual endogenous insulin secretion. Patients, who had diabetes for a mean (±SEM) of 8.4 ± 1.9 yr, had minimal or no C-peptide response at baseline evaluation. C-peptide responses remained unchanged when reassessed after 2, 4, and 6 mo of improved glycemic control.

Original languageEnglish (US)
Pages (from-to)334-336
Number of pages3
JournalDiabetes care
Volume5
Issue number3
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Advanced and Specialized Nursing

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