Lack of effect of chronically administered thyrotropin-releasing hormone (TRH) on regional rat brain tyrosine hydroxylase activity

Charles B. Nemeroff, James A. Diez, Garth Bissette, Arthur J. Prange, Lindy E. Harrell, Morris A. Lipton

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Chronic treatment of adult male rats with TRH (1 or 10 mg/kg IP) for 5 or 9 days failed to alter the activity of tyrosine hydroxylase (TH), the enzyme regulating the rate-limiting step in catecholamine biosynthesis. In contrast, as previously described, chronic reserpine administration (0.5 mg/kg IP: 9 days) resulted in a significant rise in TH activity in midbrain, hypothalamus, pons-medulla and forebrain. These results suggest that the enhanced brain norepinphrine turnover reported to occur after treatment with TRH is not due to synthesis of new TH enzyme protein.

Original languageEnglish (US)
Pages (from-to)467-469
Number of pages3
JournalPharmacology, Biochemistry and Behavior
Volume6
Issue number4
DOIs
StatePublished - Apr 1977
Externally publishedYes

Keywords

  • Reserpine
  • TRH
  • Tyrosine hydroxylase

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

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