Lack of cytomegalovirus transmission after pancreatic islet transplantation

Neal R. Barshes, Timothy C. Lee, F. Charles Brunicardi, Amy Mote, A. Paige Schock, Rodolfo Alejandro, Camillo Ricordi, John A. Goss

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

In spite of antiviral prophylaxis, the transmission rate of cytomegalovirus (CMV) after solid organ transplantation remains high. In contrast, CMV transmission has never been reported following pancreatic islet transplantation (PIT). Eleven (seven CMV seronegative, four CMV seropositive) recipients underwent a total of 26 PITs. Following PIT recipients were monitored clinically and tested monthly for CMV antigenemia. Valganciclovir was given to all patients for 100 days after each PIT. Follow-up ranged from 6 to 24 months (median 14.5 months). Pancreatic islet grafts were procured from 18 CMV seropositive and 8 seronegative donors (69% and 31% of donors, respectively). In total there were 6 R+D+, 3 R+D-, 12 R-D+, and 5 R-D-PITs. No patient developed CMV antigenemia or symptoms consistent with CMV infection at any time following PIT. Routine posttransplant testing of PIT recipients demonstrated that neither CMV transmission nor CMV infection occurred after PIT.

Original languageEnglish (US)
Pages (from-to)833-838
Number of pages6
JournalCell Transplantation
Volume13
Issue number7-8
DOIs
StatePublished - Jan 1 2004

Keywords

  • β-Cell replacement
  • Antiviral prophylaxis
  • Cytomegalovirus (CMV)
  • Pancreatic islet transplantation (PIT)

ASJC Scopus subject areas

  • Cell Biology
  • Transplantation

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  • Cite this

    Barshes, N. R., Lee, T. C., Brunicardi, F. C., Mote, A., Schock, A. P., Alejandro, R., Ricordi, C., & Goss, J. A. (2004). Lack of cytomegalovirus transmission after pancreatic islet transplantation. Cell Transplantation, 13(7-8), 833-838. https://doi.org/10.3727/000000004783983440