Lack of association of VEGF promoter polymorphisms with sporadic ALS

W. Chen, M. Saeed, H. Mao, N. Siddique, L. Dellefave, W. Y. Hung, H. X. Deng, R. L. Sufit, S. L. Heller, J. L. Haines, M. Pericak-Vance, T. Siddique

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

The authors tested the association of three vascular endothelial growth factor (VEGF) promoter polymorphisms with sporadic ALS (SALS) to verify the results of a previous study and to investigate their modifier effects on the subphenotypes of SALS in a large family-based and case-control cohort of North American white subjects (N = 1,603). They did not find any association of the VEGF promoter polymorphisms with SALS or its subphenotypes, suggesting that they do not have a direct causal role in ALS.

Original languageEnglish (US)
Pages (from-to)508-510
Number of pages3
JournalNeurology
Volume67
Issue number3
DOIs
StatePublished - Aug 2006
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology

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