Lack of association between autism and SLC25A12

Raquel Rabionet, Jacob L McCauley, James M. Jaworski, Allison E. Ashley-Koch, Eden R Martin, James S. Sutcliffe, Jonathan L. Haines, G. Robert DeLong, Ruth K. Abramson, Harry H. Wright, Michael Cuccaro, John Gilbert, Margaret A Pericak-Vance

Research output: Contribution to journalArticle

Abstract

Objective: Autism has a strong, complex genetic component, most likely involving several genes. Multiple genomic screens have shown evidence suggesting linkage to chromosome 2q31-q33, which includes the SLC25A12 gene. Recently, an association between autism risk and two single nucleotide polymorphisms (SNPs) in SLC25A12 was reported. This study aimed to test for association in SLC25A12 in an independent data set of 327 families with autistic offspring. Method: The authors analyzed two SNPs that were significant in the previous study group, as well as seven additional SNPs within the gene. Association analyses for individual SNPs as well as haplotypes were performed. Results: There was no evidence of an association between SLC25A12 and autism. Conclusions: These results suggest that SLC25A12 is not a major contributor to autism risk in these families.

Original languageEnglish
Pages (from-to)929-931
Number of pages3
JournalAmerican Journal of Psychiatry
Volume163
Issue number5
DOIs
StatePublished - May 1 2006
Externally publishedYes

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ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Rabionet, R., McCauley, J. L., Jaworski, J. M., Ashley-Koch, A. E., Martin, E. R., Sutcliffe, J. S., Haines, J. L., DeLong, G. R., Abramson, R. K., Wright, H. H., Cuccaro, M., Gilbert, J., & Pericak-Vance, M. A. (2006). Lack of association between autism and SLC25A12. American Journal of Psychiatry, 163(5), 929-931. https://doi.org/10.1176/appi.ajp.163.5.929