L1CAM mutation in association with X-linked hydrocephalus and Hirschsprung's disease

Sha Ron Jackson, Yigit S. Guner, Russell Woo, Linda M. Randolph, Henri Ford, Cathy E. Shin

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

X-linked hydrocephalus (XLH) is characterized by increased intracranial ventricle size and head circumference secondary to aqueduct of Sylvius congenital stenosis. Exceedingly rare is the concurrence of XLH and Hirschsprung's disease (HSCR) with a theoretical incidence of 1 in 125-250 million cases. Herein, we are describing a case of a patient with concurrent XLH and HSCR. The patient was delivered via cesarean section at 37 weeks gestation and underwent uneventful ventriculoperitoneal shunt placement. As a part of a workup for constipation, we performed a rectal biopsy, which was consistent with HSCR. Genetics testing showed hemizygous for R558X hemizygous mutation in the L1CAM gene. A C → T nucleotide substitution in exon 13 resulted in replacement of an arginine codon with a stop codon, a nonsense mutation. Although it is widely accepted that HSCR represents the failure of early embryonic neural crest cells to migrate properly, the exact mechanism is not known. The association of HSCR with XLH in the presence of L1CAM mutations remains quite interesting because cell adhesion molecules are involved in the proper migration of neural components throughout the body. Additional studies are necessary to fully elucidate the relationship between XLH and HSCR in the presence of L1CAM mutations.

Original languageEnglish (US)
Pages (from-to)823-825
Number of pages3
JournalPediatric Surgery International
Volume25
Issue number9
DOIs
StatePublished - Sep 1 2009
Externally publishedYes

Fingerprint

Neural Cell Adhesion Molecule L1
Hirschsprung Disease
Mutation
Cerebral Aqueduct
Ventriculoperitoneal Shunt
Terminator Codon
Neural Crest
Nonsense Codon
Cell Adhesion Molecules
Genetic Testing
Constipation
Codon
Cesarean Section
Arginine
X-linked Hydrocephalus
Exons
Pathologic Constriction
Nucleotides
Head
Biopsy

Keywords

  • Constipation
  • Hirschsprung's disease
  • Hydrocephalus
  • Neonate

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery

Cite this

L1CAM mutation in association with X-linked hydrocephalus and Hirschsprung's disease. / Jackson, Sha Ron; Guner, Yigit S.; Woo, Russell; Randolph, Linda M.; Ford, Henri; Shin, Cathy E.

In: Pediatric Surgery International, Vol. 25, No. 9, 01.09.2009, p. 823-825.

Research output: Contribution to journalArticle

Jackson, Sha Ron ; Guner, Yigit S. ; Woo, Russell ; Randolph, Linda M. ; Ford, Henri ; Shin, Cathy E. / L1CAM mutation in association with X-linked hydrocephalus and Hirschsprung's disease. In: Pediatric Surgery International. 2009 ; Vol. 25, No. 9. pp. 823-825.
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