L1-mediated axon outgrowth occurs via a homophilic binding mechanism

Vance Lemmon, Kathryn L. Farr, Carl Lagenaur

Research output: Contribution to journalArticle

362 Scopus citations

Abstract

The molecular mechanism by which the L1 cell adhesion molecule mediates neurite outgrowth has been examined. Purified L1 from mouse and L1 from chick brain were attached to nitrocellulose dishes. Both chick and mouse neurons were able to adhere to purified mouse L1 and chick L1. Both molecules promoted neurite extension from chick and mouse neurons. Addition of Fabs specific for chick L1 to the cultures inhibited chick neurite outgrowth on both mouse L1 and chick L1. These findings suggest that L1-like molecules support neurite outgrowth via a "homophilic" binding mechanism.

Original languageEnglish (US)
Pages (from-to)1597-1603
Number of pages7
JournalNeuron
Volume2
Issue number6
DOIs
StatePublished - Jun 1989
Externally publishedYes

    Fingerprint

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this