L1-mediated axon outgrowth occurs via a homophilic binding mechanism

Vance Lemmon, Kathryn L. Farr, Carl Lagenaur

Research output: Contribution to journalArticle

362 Citations (Scopus)

Abstract

The molecular mechanism by which the L1 cell adhesion molecule mediates neurite outgrowth has been examined. Purified L1 from mouse and L1 from chick brain were attached to nitrocellulose dishes. Both chick and mouse neurons were able to adhere to purified mouse L1 and chick L1. Both molecules promoted neurite extension from chick and mouse neurons. Addition of Fabs specific for chick L1 to the cultures inhibited chick neurite outgrowth on both mouse L1 and chick L1. These findings suggest that L1-like molecules support neurite outgrowth via a "homophilic" binding mechanism.

Original languageEnglish
Pages (from-to)1597-1603
Number of pages7
JournalNeuron
Volume2
Issue number6
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Neural Cell Adhesion Molecule L1
Neurons
Collodion
Neurites
Neuronal Outgrowth
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

L1-mediated axon outgrowth occurs via a homophilic binding mechanism. / Lemmon, Vance; Farr, Kathryn L.; Lagenaur, Carl.

In: Neuron, Vol. 2, No. 6, 01.01.1989, p. 1597-1603.

Research output: Contribution to journalArticle

Lemmon, Vance ; Farr, Kathryn L. ; Lagenaur, Carl. / L1-mediated axon outgrowth occurs via a homophilic binding mechanism. In: Neuron. 1989 ; Vol. 2, No. 6. pp. 1597-1603.
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