L-carnitine supplementation of a soybean-based formula in early infancy: Plasma and urine levels of carnitineand acylcarnitines

Milan Novak, Ellen F. Monkus, Maria Buch, John Silverio, Ofelia M. Clouston, Janet C. Cassady

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The absence of carnitine in the diet of normal infants results in marked reduction of plasma carnitine levels. In order to evaluate the effects of L-carnitine supplementation of soybean formula, plasma and urine levels of free carnitine and acylcarnitine were compared in infants receiving carnitine-free soybean protein-based formula and the same formula supplemented with 50 and 250 nmol/ml L-carnitine. In infants receiving soybean formula with 50 nmol/ml L-carnitine, the plasma levels of free carnitine were not significantly different from those in infants receiving formula with 250 nmol/ml L-carnitine; however, urine levels of free carnitine were significantly increased when the infants received formula with 250 nmol/ml L-carnitine. In normal full-term infants, supplementation of soybean formula with 50 nmol/ml L-carnitine was sufficient to maintain normal plasma levels that were comparable to breast-fed infants.

Original languageEnglish (US)
Pages (from-to)220-224
Number of pages5
JournalJournal of Pediatric Gastroenterology and Nutrition
Volume7
Issue number2
DOIs
StatePublished - Mar 1988

Keywords

  • L-Carnitine
  • Soybean formula
  • Supplementation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Gastroenterology

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