KLF family members regulate intrinsic axon regeneration ability

Darde L. Moore, Murray G. Blackmore, Ying Hu, Klaus H. Kaestner, John Bixby, Vance Lemmon, Jeffrey L. Goldberg

Research output: Contribution to journalArticle

374 Citations (Scopus)

Abstract

Neurons in the central nervous system (CNS) lose their ability to regenerate early in development, but the underlying mechanisms are unknown. By screening genes developmentally regulated in retinal ganglion cells (RGCs), we identified Krüppel-like factor-4 (KLF4) as a transcriptional repressor of axon growth in RGCs and other CNS neurons. RGCs lacking KLF4 showed increased axon growth both in vitro and after optic nerve injury in vivo. Related KLF family members suppressed or enhanced axon growth to differing extents, and several growth-suppressive KLFs were up-regulated postnatally, whereas growth-enhancing KLFs were down-regulated. Thus, coordinated activities of different KLFs regulate the regenerative capacity of CNS neurons.

Original languageEnglish
Pages (from-to)298-301
Number of pages4
JournalScience
Volume326
Issue number5950
DOIs
StatePublished - Oct 9 2009

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Aptitude
Axons
Regeneration
Retinal Ganglion Cells
Growth
Central Nervous System
Neurons
Optic Nerve Injuries
Genes

ASJC Scopus subject areas

  • General

Cite this

Moore, D. L., Blackmore, M. G., Hu, Y., Kaestner, K. H., Bixby, J., Lemmon, V., & Goldberg, J. L. (2009). KLF family members regulate intrinsic axon regeneration ability. Science, 326(5950), 298-301. https://doi.org/10.1126/science.1175737

KLF family members regulate intrinsic axon regeneration ability. / Moore, Darde L.; Blackmore, Murray G.; Hu, Ying; Kaestner, Klaus H.; Bixby, John; Lemmon, Vance; Goldberg, Jeffrey L.

In: Science, Vol. 326, No. 5950, 09.10.2009, p. 298-301.

Research output: Contribution to journalArticle

Moore, DL, Blackmore, MG, Hu, Y, Kaestner, KH, Bixby, J, Lemmon, V & Goldberg, JL 2009, 'KLF family members regulate intrinsic axon regeneration ability', Science, vol. 326, no. 5950, pp. 298-301. https://doi.org/10.1126/science.1175737
Moore, Darde L. ; Blackmore, Murray G. ; Hu, Ying ; Kaestner, Klaus H. ; Bixby, John ; Lemmon, Vance ; Goldberg, Jeffrey L. / KLF family members regulate intrinsic axon regeneration ability. In: Science. 2009 ; Vol. 326, No. 5950. pp. 298-301.
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