KLF family members regulate intrinsic axon regeneration ability

Darde L. Moore, Murray G. Blackmore, Ying Hu, Klaus H. Kaestner, John L. Bixby, Vance P. Lemmon, Jeffrey L. Goldberg

Research output: Contribution to journalArticle

397 Scopus citations

Abstract

Neurons in the central nervous system (CNS) lose their ability to regenerate early in development, but the underlying mechanisms are unknown. By screening genes developmentally regulated in retinal ganglion cells (RGCs), we identified Krüppel-like factor-4 (KLF4) as a transcriptional repressor of axon growth in RGCs and other CNS neurons. RGCs lacking KLF4 showed increased axon growth both in vitro and after optic nerve injury in vivo. Related KLF family members suppressed or enhanced axon growth to differing extents, and several growth-suppressive KLFs were up-regulated postnatally, whereas growth-enhancing KLFs were down-regulated. Thus, coordinated activities of different KLFs regulate the regenerative capacity of CNS neurons.

Original languageEnglish (US)
Pages (from-to)298-301
Number of pages4
JournalScience
Volume326
Issue number5950
DOIs
StatePublished - Oct 9 2009

ASJC Scopus subject areas

  • General

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    Moore, D. L., Blackmore, M. G., Hu, Y., Kaestner, K. H., Bixby, J. L., Lemmon, V. P., & Goldberg, J. L. (2009). KLF family members regulate intrinsic axon regeneration ability. Science, 326(5950), 298-301. https://doi.org/10.1126/science.1175737