Kit and melanocyte migration

James M. Grichnik

Research output: Contribution to journalComment/debatepeer-review

46 Scopus citations


As described in this issue, Alexeev and Yoon introduced a Kit-activating mutation into melanocytes. Although mitogenic in mast cells, this mutation was motogenic in melanocytes. Further, melanocytes had a reduced proliferative rate and were less differentiated. The disparate response may be due to differences in the cellular milieu of melanocytes and may have implications for normal melanocytic integration into the epidermis, nevogenesis, and melanoma.

Original languageEnglish (US)
Pages (from-to)945-947
Number of pages3
JournalJournal of Investigative Dermatology
Issue number5
StatePublished - May 2006
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology


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