Kinetics of responses to tumor antigens and mouse mammary tumor virus in BALB/cCrgl and BALB/cfC3H mice

Diana M Lopez, M. M. Sigel, V. L. Charyulu

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Abstract

Spleen cells from BALB/cCrgl mice responded to murine mammary tumor virus (MuMTV) in cell-mediated immune assays at higher levels than did the spleen cells from the syngeneic BALB/cfC3H mice. Implantation of BALB/cCrgl with a chemically induced mammary tumor and in BALB/cfC3H mice with spontaneous mammary tumors (SMT) arising in the same strain resulted in sensitization of these animals to the antigens of their tumors. Reactivities peaked 3 weeks after transplantation, whereas no positive reactions could be detected when tumors reached maximum size. A kinetic study with the use of MuMTV antigen(s) showed that the responses of lymphocytes from BALB/cfC3H with SMT followed the same pattern as that obtained with tumor antigens, which indicated that this might be a de novo sensitization. In sharp contrast, a steady type of response to MuMTV was observed with the spleen cells from BALB/cfCrgl mice; i.e., the levels of responsiveness to MuMTV did not significantly vary at any stage of tumor development. In vivo studies explored the possible relevance of the in vitro cell-mediated immunity to the host defenses. MuMTV-expressing mammary tumor cells were implanted in BALB/cCrgl and BALB/cfC3H mice. The total incidence of tumors was significantly reduced and a delay occurred in their time of appearance in BALB/cCrgl mice in relation to BALB/cfC3H animals. Thus the in vitro reactivity to MuMTV antigen(s) in BALB/cCrgl mice was found to be coincidental with a degree of protection against the development of MuMTV-expressing mammary tumors.

Original languageEnglish
Pages (from-to)191-196
Number of pages6
JournalJournal of the National Cancer Institute
Volume66
Issue number1
StatePublished - Jan 1 1981

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Mouse mammary tumor virus
Neoplasm Antigens
Gammaretrovirus
Breast Neoplasms
Spleen
Neoplasms
Cellular Immunity

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Kinetics of responses to tumor antigens and mouse mammary tumor virus in BALB/cCrgl and BALB/cfC3H mice. / Lopez, Diana M; Sigel, M. M.; Charyulu, V. L.

In: Journal of the National Cancer Institute, Vol. 66, No. 1, 01.01.1981, p. 191-196.

Research output: Contribution to journalArticle

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