Kinetics of corneal thermal shrinkage

David Borja, Fabrice Manns, William Lee, Jean Marie Parel

Research output: Contribution to journalConference articlepeer-review

3 Scopus citations


The purpose of this study was to determine the effects of temperature and heating duration on the kinetics of thermal shrinkage in corneal strips using a custom-made shrinkage device. Methods: Thermal shrinkage was induced and measured in corneal strips under a constant load placed while bathed in 25% Dextran irrigation solution. A study was performed on 57 Florida Lions Eye Bank donated human cadaver eyes to determine the effect of temperature on the amount and rate of thermal shrinkage. Further experiments were performed on 20 human cadaver eyes to determine the effects of heating duration on permanent shrinkage. Data analysis was performed to determine the effects of temperature, heating duration, and age on the amount and kinetics of shrinkage. Results: Shrinkage consisted of two phases: a shrinkage phase during heating and a regression phase after heating. Permanent shrinkage increased with temperature and duration. The shrinkage and regression time constants followed Arrhenius type temperature dependence. The shrinkage time constants where calculated to be 67, 84, 121, 560 and 1112 (s) at 80, 75, 70, 65, and 60°C respectively. At 65°C the permanent shrinkage time constant was calculated to be 945s. Conclusion: These results show that shrinkage treatments need to raise the temperature of the tissue above 75°C for several seconds in order to prevent regression of the shrinkage effect immediately after treatment and to induce the jpaximum amount of permanent irreversible shrinkage.

Original languageEnglish (US)
Article number5314-15
Pages (from-to)79-87
Number of pages9
JournalProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Issue number3
StatePublished - Dec 1 2004
EventOphthalmic Technologies XIV - San Jose, CA, United States
Duration: Jan 24 2004Jan 27 2004


  • Collagen shrinkage dynan
  • Cornea
  • Thermal keratoplasty

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging


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