Kinetics of charged antibiotic penetration into human intervertebral discs: A numerical study

Qiaoqiao Zhu, Xin Gao, Na Li, Weiyong Gu, Frank J Eismont, Mark Brown

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Little quantitative information exists on the kinetics of charged antibiotic penetration into human intervertebral discs (IVD). This information is crucial for determining the dosage to use, timing of administration, and duration of treatment for infected IVDs. The objective of this study was to quantitatively analyze the transport of various charged antibiotics into human lumbar IVDs. Penetration of charged and uncharged antibiotics into a human lumbar disc was analyzed using a 3D finite element model. The valence (z) of the electrical charge of antibiotics varied from . z=+2 (positively charged) to . z=-2 (negatively charged). An uncharged antibiotic (z=0) was used as a control. Cases with intravenous (IV) administrations of different charged antibiotics were simulated. Our results showed that the electrical charge had great effects on kinetics of an antibiotic penetration into the IVD; with higher concentrations and uptakes for positively charged antibiotics than those for negatively charged ones. This study provides quantitative information on selecting antibiotics for treating intervertebral disc infections.

Original languageEnglish (US)
JournalJournal of Biomechanics
DOIs
StateAccepted/In press - 2016

Fingerprint

Intervertebral Disc
Antibiotics
Anti-Bacterial Agents
Kinetics
Intravenous Administration

Keywords

  • Antibiotic penetration
  • Disc infections
  • Finite element analysis
  • Intervertebral disc
  • Mixture theory
  • Transport phenomena

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Rehabilitation
  • Biophysics
  • Biomedical Engineering

Cite this

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title = "Kinetics of charged antibiotic penetration into human intervertebral discs: A numerical study",
abstract = "Little quantitative information exists on the kinetics of charged antibiotic penetration into human intervertebral discs (IVD). This information is crucial for determining the dosage to use, timing of administration, and duration of treatment for infected IVDs. The objective of this study was to quantitatively analyze the transport of various charged antibiotics into human lumbar IVDs. Penetration of charged and uncharged antibiotics into a human lumbar disc was analyzed using a 3D finite element model. The valence (z) of the electrical charge of antibiotics varied from . z=+2 (positively charged) to . z=-2 (negatively charged). An uncharged antibiotic (z=0) was used as a control. Cases with intravenous (IV) administrations of different charged antibiotics were simulated. Our results showed that the electrical charge had great effects on kinetics of an antibiotic penetration into the IVD; with higher concentrations and uptakes for positively charged antibiotics than those for negatively charged ones. This study provides quantitative information on selecting antibiotics for treating intervertebral disc infections.",
keywords = "Antibiotic penetration, Disc infections, Finite element analysis, Intervertebral disc, Mixture theory, Transport phenomena",
author = "Qiaoqiao Zhu and Xin Gao and Na Li and Weiyong Gu and Eismont, {Frank J} and Mark Brown",
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T2 - A numerical study

AU - Zhu, Qiaoqiao

AU - Gao, Xin

AU - Li, Na

AU - Gu, Weiyong

AU - Eismont, Frank J

AU - Brown, Mark

PY - 2016

Y1 - 2016

N2 - Little quantitative information exists on the kinetics of charged antibiotic penetration into human intervertebral discs (IVD). This information is crucial for determining the dosage to use, timing of administration, and duration of treatment for infected IVDs. The objective of this study was to quantitatively analyze the transport of various charged antibiotics into human lumbar IVDs. Penetration of charged and uncharged antibiotics into a human lumbar disc was analyzed using a 3D finite element model. The valence (z) of the electrical charge of antibiotics varied from . z=+2 (positively charged) to . z=-2 (negatively charged). An uncharged antibiotic (z=0) was used as a control. Cases with intravenous (IV) administrations of different charged antibiotics were simulated. Our results showed that the electrical charge had great effects on kinetics of an antibiotic penetration into the IVD; with higher concentrations and uptakes for positively charged antibiotics than those for negatively charged ones. This study provides quantitative information on selecting antibiotics for treating intervertebral disc infections.

AB - Little quantitative information exists on the kinetics of charged antibiotic penetration into human intervertebral discs (IVD). This information is crucial for determining the dosage to use, timing of administration, and duration of treatment for infected IVDs. The objective of this study was to quantitatively analyze the transport of various charged antibiotics into human lumbar IVDs. Penetration of charged and uncharged antibiotics into a human lumbar disc was analyzed using a 3D finite element model. The valence (z) of the electrical charge of antibiotics varied from . z=+2 (positively charged) to . z=-2 (negatively charged). An uncharged antibiotic (z=0) was used as a control. Cases with intravenous (IV) administrations of different charged antibiotics were simulated. Our results showed that the electrical charge had great effects on kinetics of an antibiotic penetration into the IVD; with higher concentrations and uptakes for positively charged antibiotics than those for negatively charged ones. This study provides quantitative information on selecting antibiotics for treating intervertebral disc infections.

KW - Antibiotic penetration

KW - Disc infections

KW - Finite element analysis

KW - Intervertebral disc

KW - Mixture theory

KW - Transport phenomena

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