Kinetically directed combination therapy with adriamycin and X-irradiation in a mammary tumor model

Paul G. Braunschweiger, Larry L. Schenken, Lewis M. Schiffer

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

In the present studies, the interaction of adriamycin (A) and x-irradiation (X) in T1699 mouse mammary tumors was evaluated. Mitotic indices and thymidine labeling indices were determined at various intervals after A or X alone, and after A + X given in combination. The results with A (1.0 mg/kg) and X (200 R) alone suggests that those quantities of each agent induce a G2 progression delay of 9-12 brs. The kinetic results after A + X in combination indicated increased S phase transit. time and G2 progression delay. Recovery kinetics after A + X were used to predict "optimmn" sequence intervals for subsequent A + X fractions. Sequential A + X treatment schedules, up to 4 fractions, were designed and evaluated by regrowth delay measurements. The results indicated that the interaction was additive when A and X were given together in combination. Fractionation of A + X to minimize proliferstive recovery between fractions resulted in an enhanced antitumor effect.

Original languageEnglish (US)
Pages (from-to)747-753
Number of pages7
JournalInternational Journal of Radiation Oncology, Biology, Physics
Volume7
Issue number6
DOIs
StatePublished - Jun 1981

Keywords

  • Adriamycin
  • Cell kinetics
  • Mammary tumors
  • X-irradiation

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

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