Kinematic MRI study of upper-airway biomechanics using electrical muscle stimulation

Michael J. Brennick, Susan S. Margulies, John Ford, Warren B. Gefter, Allan I. Pack

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

We have developed a new and powerful method to study the movement and function of upper airway muscles. Our method is to use direct electrical stimulation of individual upper airway muscles, while performing state of the art high resolution magnetic resonance imaging (MRI). We have adapted a paralyzed isolated UA cat model so that positive or negative static pressure in the UA can be controlled at specific levels while electrical muscle stimulation is applied during MRI. With these techniques we can assess the effect of muscle stimulation on airway cross-sectional area compliance and soft tissue motion. We are reporting the preliminary results and MRI techniques which have enabled us to examine changes in airway dimensions which result form electrical stimulation of specific upper airway dilator muscles. The results of this study will be relevant to the development of new clinical treatments for obstructive sleep apnea by providing new information as to exactly how upper airway muscles function to dilate the upper airway and the strength of stimulation required to prevent the airway obstruction when overall muscle tone may not be sufficient to maintain regular breathing.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages50-56
Number of pages7
Volume3033
ISBN (Print)0819424447
StatePublished - 1997
Externally publishedYes
EventMedical Imaging 1997: Physiology and Function from Multidimensional Images - Newport Beach, CA, USA
Duration: Feb 23 1997Feb 25 1997

Other

OtherMedical Imaging 1997: Physiology and Function from Multidimensional Images
CityNewport Beach, CA, USA
Period2/23/972/25/97

Fingerprint

biodynamics
Biomechanics
Magnetic resonance
muscles
stimulation
magnetic resonance
Muscle
Kinematics
kinematics
Imaging techniques
sleep
static pressure
cats
respiration
breathing
imaging techniques
Tissue
high resolution

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Brennick, M. J., Margulies, S. S., Ford, J., Gefter, W. B., & Pack, A. I. (1997). Kinematic MRI study of upper-airway biomechanics using electrical muscle stimulation. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3033, pp. 50-56). Society of Photo-Optical Instrumentation Engineers.

Kinematic MRI study of upper-airway biomechanics using electrical muscle stimulation. / Brennick, Michael J.; Margulies, Susan S.; Ford, John; Gefter, Warren B.; Pack, Allan I.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3033 Society of Photo-Optical Instrumentation Engineers, 1997. p. 50-56.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Brennick, MJ, Margulies, SS, Ford, J, Gefter, WB & Pack, AI 1997, Kinematic MRI study of upper-airway biomechanics using electrical muscle stimulation. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3033, Society of Photo-Optical Instrumentation Engineers, pp. 50-56, Medical Imaging 1997: Physiology and Function from Multidimensional Images, Newport Beach, CA, USA, 2/23/97.
Brennick MJ, Margulies SS, Ford J, Gefter WB, Pack AI. Kinematic MRI study of upper-airway biomechanics using electrical muscle stimulation. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3033. Society of Photo-Optical Instrumentation Engineers. 1997. p. 50-56
Brennick, Michael J. ; Margulies, Susan S. ; Ford, John ; Gefter, Warren B. ; Pack, Allan I. / Kinematic MRI study of upper-airway biomechanics using electrical muscle stimulation. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3033 Society of Photo-Optical Instrumentation Engineers, 1997. pp. 50-56
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