Abstract
Short interfering RNAs can be used to silence gene expression in a sequence-specific manner in a process that is known as RNA interference. The application of RNA interference in mammals has the potential to allow the systematic analysis of gene expression and holds the possibility of therapeutic gene silencing. Much of the promise of RNA interference will depend on the recent advances in short-RNA-based silencing technologies.
| Original language | English |
|---|---|
| Pages (from-to) | 457-467 |
| Number of pages | 11 |
| Journal | Nature Reviews Molecular Cell Biology |
| Volume | 4 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Molecular Biology
- Cell Biology
Cite this
Killing the messenger : Short RNAs that silence gene expression. / Dykxhoorn, Derek M; Novina, Carl D.; Sharp, Phillip A.
In: Nature Reviews Molecular Cell Biology, Vol. 4, No. 6, 01.06.2003, p. 457-467.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Killing the messenger
T2 - Short RNAs that silence gene expression
AU - Dykxhoorn, Derek M
AU - Novina, Carl D.
AU - Sharp, Phillip A.
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Short interfering RNAs can be used to silence gene expression in a sequence-specific manner in a process that is known as RNA interference. The application of RNA interference in mammals has the potential to allow the systematic analysis of gene expression and holds the possibility of therapeutic gene silencing. Much of the promise of RNA interference will depend on the recent advances in short-RNA-based silencing technologies.
AB - Short interfering RNAs can be used to silence gene expression in a sequence-specific manner in a process that is known as RNA interference. The application of RNA interference in mammals has the potential to allow the systematic analysis of gene expression and holds the possibility of therapeutic gene silencing. Much of the promise of RNA interference will depend on the recent advances in short-RNA-based silencing technologies.
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UR - http://www.scopus.com/inward/citedby.url?scp=0037686295&partnerID=8YFLogxK
U2 - 10.1038/nrm1129
DO - 10.1038/nrm1129
M3 - Article
C2 - 12778125
AN - SCOPUS:0037686295
VL - 4
SP - 457
EP - 467
JO - Nature Reviews Molecular Cell Biology
JF - Nature Reviews Molecular Cell Biology
SN - 1471-0072
IS - 6
ER -