Killing the messenger: Short RNAs that silence gene expression

Derek M. Dykxhoorn; Carl D. Novina; Phillip A. Sharp

doi:10.1038/nrm1129

Killing the messenger: Short RNAs that silence gene expression

Derek M. Dykxhoorn, Carl D. Novina, Phillip A. Sharp

Research output: Contribution to journal › Review article › peer-review

1000 Scopus citations

Abstract

Short interfering RNAs can be used to silence gene expression in a sequence-specific manner in a process that is known as RNA interference. The application of RNA interference in mammals has the potential to allow the systematic analysis of gene expression and holds the possibility of therapeutic gene silencing. Much of the promise of RNA interference will depend on the recent advances in short-RNA-based silencing technologies.

Original language	English (US)
Pages (from-to)	457-467
Number of pages	11
Journal	Nature Reviews Molecular Cell Biology
Volume	4
Issue number	6
DOIs	https://doi.org/10.1038/nrm1129
State	Published - Jun 1 2003
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/nrm1129

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title = "Killing the messenger: Short RNAs that silence gene expression",

abstract = "Short interfering RNAs can be used to silence gene expression in a sequence-specific manner in a process that is known as RNA interference. The application of RNA interference in mammals has the potential to allow the systematic analysis of gene expression and holds the possibility of therapeutic gene silencing. Much of the promise of RNA interference will depend on the recent advances in short-RNA-based silencing technologies.",

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AU - Sharp, Phillip A.

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AB - Short interfering RNAs can be used to silence gene expression in a sequence-specific manner in a process that is known as RNA interference. The application of RNA interference in mammals has the potential to allow the systematic analysis of gene expression and holds the possibility of therapeutic gene silencing. Much of the promise of RNA interference will depend on the recent advances in short-RNA-based silencing technologies.

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Killing the messenger: Short RNAs that silence gene expression

Abstract

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