Killing the messenger: Short RNAs that silence gene expression

Derek M. Dykxhoorn, Carl D. Novina, Phillip A. Sharp

Research output: Contribution to journalReview articlepeer-review

1000 Scopus citations


Short interfering RNAs can be used to silence gene expression in a sequence-specific manner in a process that is known as RNA interference. The application of RNA interference in mammals has the potential to allow the systematic analysis of gene expression and holds the possibility of therapeutic gene silencing. Much of the promise of RNA interference will depend on the recent advances in short-RNA-based silencing technologies.

Original languageEnglish (US)
Pages (from-to)457-467
Number of pages11
JournalNature Reviews Molecular Cell Biology
Issue number6
StatePublished - Jun 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Killing the messenger: Short RNAs that silence gene expression'. Together they form a unique fingerprint.

Cite this