Kidney and pancreas transplantation in the United States, 1997-2006: The HRSA breakthrough collaboratives and the 58 DSA challenge

A. B. Leichtman, D. Cohen, D. Keith, K. O'Connor, M. Goldstein, V. McBride, C. J. Gould, L. L. Christensen, V. B. Ashby

Research output: Contribution to journalReview articlepeer-review

92 Scopus citations


Growth in the number of active patients on the kidney transplant waiting list has slowed. Projections based on the most recent 5-year data suggest the total waiting list will grow at a rate of 4138 registrations per year, whereas the active waiting list will increase at less than one-sixth that rate, or 663 registrations per year. The last 5 years have seen a small trend toward improved unadjusted allograft survival for living and deceased donor kidneys. Since 2004 the overall number of pancreas transplants has declined. Among pancreas recipients, those with simultaneous kidney-pancreas transplants experienced the highest pancreas graft survival rates. In response to the ongoing shortage of deceased donor organs, the US Health Resources and Services Administration launched the Organ Donation Breakthrough Collaborative in September 2003 and the Organ Transplantation Breakthrough Collaborative (OTBC) in October 2005. The 58 DSA Challenge is prominent among the goals adopted by the OTBC. Its premise: were each of the 58 existing donation service areas to increase the number of kidney transplants performed within their boundaries by 10 per month, an additional 7000 transplants over current annual levels would result. Such an increase could potentially eliminate the national kidney transplantation waiting list by 2030.

Original languageEnglish (US)
Pages (from-to)946-957
Number of pages12
JournalAmerican Journal of Transplantation
Issue number4 PART 2
StatePublished - Apr 2008
Externally publishedYes


  • 58 DSA Challenge
  • 7000 Kidney Challenge
  • Deceased donor kidneys
  • Donation service areas
  • Expanded criteria donors
  • Kidney transplantation
  • Living donor transplantation
  • OPTN
  • Organ Donation Breakthrough Collaborative
  • Organ procurement organization

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)


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